Runx proteins (also known as Runt-domain transcription factors) have been studied for a long time as key regulators of cellular differentiation. RUNX2 has been described as essential for osteogenesis, whereas RUNX1 and RUNX3 are known to control ...

We show that Runx1 and Runx3 function together to drive T-lineage commitment, binding the same sites. Double knockouts block both activation of T-lineage genes and repression of progenitor genes.

2023年5月27日 · 该研究证明，地西他滨对Runx3的甲基化重编程在低剂量地西他滨和抗PD-1组合改善治疗反应中起关键作用，并且Runx3的表达水平是抗PD-1治疗反应的潜在生物标志物。 作者团队招募了两组接受抗PD-1治疗与抗PD-1/DAC（DP）治疗的患者。 从患者外周血中分离CD8+ T细胞，采用EPIC分析DNA甲基化，采用RNA-seq分析表达谱，并使用IPA和GSEA功能注释进行多组分析。 如图1所示，与抗PD-1治疗的患者相比，在DAC引发的抗PD-1治疗患者中检测到大规 …

In this Review, we examine the mechanisms by which RUNX complexes act together with other transcription factors, such as Th-POK (T-helper-inducing POZ/Kruppel-like factor) and GATA-binding protein 3 (GATA3) in determining the CD4/CD8 lineage choice of developing thymocytes.

2022年7月26日 · We show that Runx3 enforced tissue residency in CD8 + T cells through a TGF-β-dependent transcriptional mechanism that was absent in CD4 + T RM cells.

In this Review, we examine the mechanisms by which RUNX complexes act together with other transcription factors, such as Th-POK (T-helper-inducing POZ/Kruppel-like factor) and GATA-binding...

Runx family transcription factors (Runx1, Runx2, Runx3, and their cofactor CBFβ) are important for T cell development from the earliest steps in the lineage, playing partially redundant roles 1 – 5.

2021年8月6日 · In this review, we discuss the diversity of Runx functions in mature T helper cells, such as production of cytokines and chemokines by different CD4 T cell populations; apoptosis; and immunologic memory acquisition. We then briefly cover recent findings about the contribution of RUNX1, RUNX2 and RUNX3 to various immunologic diseases. Finally ...

2018年4月17日 · We mapped regions of hyper-accessible chromatin in naive cells during TCR stimulation and discovered that the transcription factor (TF) Runx3 promoted accessibility to memory CTL-specific cis -regulatory regions before the first cell division and was essential for memory CTL differentiation.

We show that Runx1 and Runx3 function together to drive T-lineage commitment, binding the same sites. Double knockouts block both activation of T-lineage genes and repression of progenitor genes.