2024年5月23日 · A novel blood-based in vitro diagnostic test determines the calcification propensity in patients, e.g. chronic kidney disease (CKD) patients. This assay is known as the ‘T50 test’ and is based on the one-half maximal transition time (T50; minutes) of calciprotein particle 1 (CPP1) to calciprotein particle 2 (CPP2) in serum (Fig. 1).

The T50 blood test is a new modifiable cardiovascular risk factor: poor T50 values are strongly associated with poor cardiovascular prognosis. Optimized therapies can improve the T50, and thus patient prognosis. The T50 measures the Calcification Propensity, and thus the endogenous defense capacity against calcification.

2020年4月7日 · The T50 test is a functional global assay measuring CPP transformation, which is influenced by low molecular regulators of mineralization like pyrophosphate and magnesium as well as large molecular weight plasma-derived mineral chaperone proteins [18].

2020年4月7日 · The T50 test is a functional global assay measuring CPP transformation, which is influenced by low molecular regulators of mineralization like pyrophosphate and magnesium as well as large molecular weight plasma-derived mineral chaperone proteins [18].

2017年12月20日 · A functional assay (T50-test) measuring the propensity of human serum to calcify associates with mortality and cardiovascular events in CKD patients. Calcification propensity is known to...

The T50 is a novel in vitro diagnostic bioassay which provides a functional read-out of the crystallization of calcium phosphate in human blood, which drives the calcification process. This T50 in turn correlates independently with the patient*s cardiovascular risk.

2022年9月15日 · A recently developed serum calcification propensity assay is based on the half-transformation time (T50) from primary calciprotein particles (CPPs) to secondary CPPs, reflecting the serum's endogenous capacity to prevent calcium phosphate precipitation.

2020年4月7日 · The speed and reproducibility of the T50 chip-based assay run at 75°C suggest that it may be suitable for rapid measurements, preferably in-line in a dialyser or in a portable microfluidic ...

2022年6月28日 · Serum calcification propensity T50 is a blood test measuring the functional anticalcifying buffer capacity of serum. Here, we evaluated T50 in PXE patients aiming to investigate its determinants and suitability as a potential biomarker for disease severity.

2024年11月9日 · The first one is to analyse the change of T50 during haemodialysis treatments. The second primary objective is to determine the effect of pre-analytical variables on the T50 measurements,…