周小龙、王恩多研究组合作揭示人线粒体tRNA t 6 A修饰的分子机 …
2020年2月12日 · 该研究揭示了人线粒体tRNA反密码子环第37位腺嘌呤 N6 -苏氨酰基甲腺苷酸 (N6 -Threonylcarbamoyladenosine, t 6 A)修饰的分子机制。 t 6 A修饰是广泛存在于三界生物中，负 …
人细胞质tRNA t6A修饰的底物选择机制及功能 - 生物通
该研究明确人所有的ANN解码tRNA均具有 t6A 修饰，发现 t6A 修饰机器与tRNA Met i的协同进化，首次阐明真核生物KEOPS识别tRNA底物的分子机制，揭示 t6A 修饰是hIleRS识别tRNA Ile …
Molecular basis for t6A modification in human mitochondria
2020年4月6日 · N 6-Threonylcarbamoyladenosine (t6A) is a universal tRNA modification essential for translational accuracy and fidelity. In human mitochondria, YrdC synthesises an l …
In vitro biosynthesis of a universal t6A tRNA modification in …
2012年12月19日 · Here, we reconstituted for the first time an in vitro system for t 6 A modification in Archaea and Eukarya, using purified KEOPS and Sua5. We demonstrated binding of tRNAs …
Conservation and Diversification of tRNA t6A-Modifying Enzymes …
2022年11月6日 · The universal N6 -threonylcarbamoyladenosine (t 6 A) modification occurs at position 37 of tRNAs that decipher codons starting with adenosine. Mechanistically, t 6 A …
Modified nucleosides and conformation of anticodon loops: crystal ...
Efficient conversion of N 6 -threonylcarbamoyladenosine (t 6 A) into a tRNA native hydantoin cyclic form (ct 6 A) performed at nucleoside and oligoribonucleotide levels.
Defects in t6A tRNA modification due to GON7 and YRDC
2019年9月3日 · Nature Communications - The biosynthesis of N6-threonylcarbamoylated adenosine 37 in tRNA (t6A) involves the YRDC enzyme and the KEOPS complex. Here, the …
Modified nucleosides and conformation of anticodon loops: crystal ...
1977年11月15日 · Modified nucleosides and conformation of anticodon loops: crystal structure of t6A and g6A Biochemistry . 1977 Nov 15;16(23):4999-5008. doi: 10.1021/bi00642a010.
Specificity in the biosynthesis of the universal tRNA nucleoside
N6-threonylcarbamoyl adenosine (t6A) is a nucleoside modification found in all kingdoms of life at position 37 of tRNAs decoding ANN codons, which functions in part to restrict translation …
Conservation and Diversification of tRNA t6A-Modifying Enzymes …
2022年11月6日 · The universal N6-threonylcarbamoyladenosine (t6A) modification occurs at position 37 of tRNAs that decipher codons starting with adenosine. Mechanistically, t6A …