Yeast TFIID comprises the TATA binding protein and 14 TBP-associated factors (TAFIIs), nine of which contain histone-fold domains (INTERPRO). The C-terminal region of the TFIID-specific yeast TAF4 (yTAF4) containing the HFD shares strong sequence similarity with Drosophila (d)TAF4 and human TAF4.

2024年12月25日 · TAF4 (TATA-Box Binding Protein Associated Factor 4) is a Protein Coding gene. Diseases associated with TAF4 include Intellectual Developmental Disorder, Autosomal Dominant 73 and Non-Specific Syndromic Intellectual Disability .

2023年1月13日 · Our results reveal a novel function of Taf4 in antagonizing PRC2-mediated repression of the stem cell gene expression program to assure normal development, homeostasis, and...

De novo putative loss-of-function variants in TAF4 are associated with a neuro-developmental disorder. alphaalpha-hub coregulator structure and flexibility determine transcription factor binding and selection in regulatory interactomes.

2024年12月25日 · This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene.

TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.

TAF是在TDF基础上研发生产的最新抗病毒药物，与TDF相比，TAF的体外血浆半衰期达31分钟，是TDF（半衰期0.4分钟）的78倍；同时，TAF可靶向送至肝细胞，使靶细胞内的药物浓度大幅度提高。 TAF每片25毫克，只需不到TDF十分之一的药量就可以达到相当的抗病毒效果。 服用TAF后转氨酶复常率更高，但是不会造成肾脏和骨骼损伤，目前未出现一例耐药发生。 一直以来，乙肝药物昂贵的价格也是导致乙肝患者无法得到良好治疗的重要因素。 可以说，乙肝患者不仅要长 …

2008年10月3日 · We show here that OMA-1 and OMA-2, previously shown to regulate oocyte maturation, repress transcription in P0 and P1 by binding to and sequestering in the cytoplasm TAF-4, a component critical for assembly of TFIID and the pol II preinitiation complex.

TAF4 was identified as an ASD candidate gene based on having a p-value < 0.001 following DeNovoWEST analysis of de novo variants in 16,877 ASD trios from the Simons Simplex Collection, the Autism Sequencing Consortium, the MSSNG cohort, and the SPARK cohort in Zhou et al., 2022; among the de novo variants observed in ASD cases in this analysis w...

2008年10月3日 · We show here that OMA-1 and OMA-2, previously shown to regulate oocyte maturation, repress transcription in P0 and P1 by binding to and sequestering in the cytoplasm TAF-4, a component critical for assembly of TFIID and the pol II preinitiation complex.