2015年1月30日 · Numerous studies show that anti-TB drugs can be incorporated into liposomes, microparticles or nanoparticles which can be delivered as dry powders to the deep lungs for instantaneous, targeted and/or controlled release.

Total value of FPF currently stands at USD 6,560,000 million, in which USD 4,700,000 million is funded by USAID and USD 1,860,000 million is from STBP’s own funding. • USAID funding will be used for USAID priority countries (Tier 1 and Tier 2)

use part of its funds to set up a Flexible Procurement Fund (FPF) to function as a treasury facility. In addition, Stop TB Partnership (STBP) has decided to allocate funds from its savings over the past period to the FPF. This would offer guarantees to Procurement Agents

2022年7月1日 · The aerodynamic properties like mass median aerodynamic diameter (MMAD), emitted dose (ED), fine particle dose (FPD), and fine particle fraction (FPF) of the produced DPIs affect its therapeutic efficiency. Particles with <5 μm aerodynamic diameter are mainly deposited in the deep lung, whereas smaller particles of around 1 μm are exhaled out.

12-14 December 2024, Abuja, Nigeria; 6-8 February 2024, Brasilia, Brazil. 23-26 March 2023, Varanasi, India; 19-20 May 2022, Hybrid; 28-30 September 2021, Virtual

2019年7月7日 · The current standard first-line multi-drug treatment regimen for TB involves rifampicin (RIF), ethambutol (EMB), isoniazid (INH), and pyrazinamide (PZA). But the incidence of MDR-TB and XDR-TB strains is increasing which is alarming as they do not respond to the existing orally administered first-line therapeutics .

2020年7月11日 · 利福平是目前口服使用的一线高效药物，作为抗结核 (TB) 长期多药治疗方案的一部分。 尽管吸入疗法具有作为治疗结核病的有效方法的潜力，但尚未开发出可用于临床应用的利福平吸入制剂。 为此，有必要评估其固态特性，这些特性调节了溶解度、溶解度、雾化、稳定性和生物利用度等重要特性。 在这项研究中，结晶技术和喷雾干燥用于制备可吸入利福平制剂。 喷雾干燥产生利福平的无定形制剂，而结晶二水合物和五水合物制剂通过结晶获得。 评估粉末的固 …

2020年8月10日 · The formulation was evaluated for activity against M.tb in macrophage cultures and in mice model infected with a low-dose bacterial (~100 CFU) aerosol. The inhalation of NAC/PLGA-MPP encapsulated with IDR-1018 significantly reduced (p < .05) bacterial load (up to ~3.02LogCFU/ml) and inflammation in lungs in a mouse model of TB compared to ...

有效部位沉积量是气雾剂质量检查中的一个指标，通常粒径为1.0-5.0μm的药物，被认为可优先到达肺部，也称为微小粒子部分（FPF）。 这些粒子在细支气管和肺泡内沉积的量称为有效部位沉积量。

2017年3月4日 · FPD：fine particle dose，微细粒子剂量；指随驱动从装置发射的、以小于规定极限的空气动力学粒径存在的活性剂的总质量。 如果没有明确说明设定为其他的极限，例如3μm或1μm等，通常将该极限设定为5μm。 FPD是使用冲击器或碰撞器，例如两级碰撞器 (TSI)、多级碰撞器 (MSI)、Andersen级联碰撞计或下一代冲击器 (NGI)来测量的。 FPF：fine particle fraction ，微细离子分数；定义为FPD除以发射剂量并且以百分数来表示。 MMAD ：mass median …