
文献分享:Nemo样激酶(NLK)可作为DBA治疗的潜在靶点
Diamond Blackfan Anemia(DBA)是一种先天性骨髓衰竭综合征,与核糖体基因突变有关,导致核糖体功能不全。 DBA的特征在于贫血,先天性异常和 癌症易感性。 DBA的治疗与高发病率有关,在本研究中,我们鉴定了Nemo样激酶(NLK)可作为DBA治疗得潜在靶点。 为了确定新的DBA靶标,我们筛选了在DBA小鼠模型中会增加红系扩展的小分子,该筛选鉴定出抑制NLK的化合物。 NLK的化学和遗传抑制作用会增加小鼠和人类祖细胞(包括来自DBA患者的骨髓细胞) …
Nemo样激酶在肿瘤发生发展中的双重作用 - 仁和软件
摘要:Nemo样激酶(Nemo-like kinase,NLK)是一种进化上保守的促分裂原活化蛋白激酶类似的激酶,属于丝氨酸/苏氨酸蛋白激酶超家族成员.NLK可以通过参与Wnt、Notch、FoxO等多条通路调节细胞增殖、分化、胚胎发育早期形态学变化和脊椎动物神经系统发育等生物过程.NLK还是 ...
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NLK Gene - GeneCards | NLK Protein | NLK Antibody
2024年12月25日 · Enables DNA-binding transcription factor binding activity; protein serine/threonine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of TORC1 signaling; protein stabilization; and transforming growth factor beta receptor signaling pathway.
Therapeutic Targeting of Nemo-like Kinase in Primary and …
2021年5月1日 · Here, we report Nemo-like kinase (NLK) as a new actionable kinase target that endows previously uncharacterized survival signaling in endocrine-resistant breast cancer. Experimental design: The effects of NLK inhibition on the viability of endocrine-resistant breast cancer cell lines were examined by MTS assay.
Nemo 样激酶(Nemo-like kinase,NLK )在前列腺癌组织中的表达水平较良性组织显著降低,并且在前列腺癌细胞中沉默NLK 表达可增强核因子-κB(nuclear factor-κB,NF-κB )的转录活性。 本研究旨在探讨NLK 调控前列腺炎-癌转化的作用及其机制,为应用抗炎新策略预防前列腺癌提供新的分子靶点和理论依据。 方法:采用人前列腺上皮细胞RWPE-1 与人急性单核细胞白血病细胞THP-1共培养的方法建立前列腺炎- 癌转化细胞模型(RWPE-1/THP-1 )。 采用MTT 实验及软琼脂集落形成实 …
结核感染T细胞(TB-IGRA)检测及意义 - 百度文库
•原理: 感染者体内被结核菌(tb)抗原致敏的效应t细胞, 在体外受到相同抗原的刺激(在apc辅助下)后,会分泌大 量ifn- γ(细胞因子)。 通过IFN- γ的检测,判断结核感染情况。
NLK在IL-1β诱导C/EBP信号通路激活和SRF介导肌细胞分化中的作 …
Nemo样蛋白激酶 (Nemo-like kinase, NLK)是一个和MAPK以及CDK都有较高同源性的蛋白激酶.同MAPK及CDK一样,NLK也参与了许多信号通路的调控.从无脊椎的蠕虫到人,NLK是进化上保守的.无论在无脊椎动物还是在小鼠和人中,NLK都与许多尚未完全清楚的表型及疾病相关.因此,探索新的NLK调控的信号通路和功能不仅有助于认识与NLK相关的表型,而且为将来预防和治疗与NLK相关疾病提供了理论基础.本论文研究发现了NLK在IL-1β诱导的C/EBP信号通路以及SRF介导的肌细 …
Thomas & Betts NLK-2/0-TB - Sager
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Nlk大鼠基因|Nlk基因信息|Nlk蛋白相互作用-RDDC官网
Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis. Predicted to enable several functions, including ATP binding activity; SH2 domain binding activity; and magnesium ion binding activity.