To achieve this, I review three core areas for fMRI research in TBI: how to understand BOLD fMRI signals in the injured brain, major analytic approaches applied to fMRI data in TBI, and important frontiers to achieve a mature network science in fMRI research applied to TBI.

These authors investigated resting-state functional connectivity using fMRI in a sample of 20 TBI patients and 21 age-matched controls, and then used graph-theoretical methods and multivariate statistical models to infer relationships between changes in functional connectivity, on the one hand, and TBI-related white matter damage as measured ...

2019年12月1日 · Dynamic susceptibility-weighted contrast-enhanced perfusion MRI, MR arterial spin labeling, and perfusion CT are reviewed as methods for examining cerebral blood flow following TBI. The authors evaluate MR-based diffusion tensor imaging and functional MRI for prognostication of recovery post-TBI.

2007年2月1日 · Functional MRI (fMRI) provides relatively high-resolution indirect assessment of neuronal activity. Three main factors interact to affect the quality of fMRI data that is acquired: (1) MRI hardware, (2) the paradigm (or experimental) design, and (3) subject cooperation. This article focuses on paradigm design and subject cooperation.

血氧水平依赖fMRI（blood oxygenation-level dependent fMRI, BOLD-fMRI）是一种利用顺磁脱氧血红蛋白和抗磁性氧合血红蛋白之间产生的内源性信号对比从而反映脑组织功能变化的fMRI技术。

创伤性脑损伤（traumatic brain injury， TBI）是重要的脑损伤性疾病，是神经外科最常见的疾病及导致创伤患者伤残及死亡的主要原因。 轻度TBI（mild TBI， mTBI）定义为患者头部受到外来暴力后，最初的格拉斯哥昏迷评分（Glasgowscore， GCS）13～15分、意识丧失持续时间 ...

2020年1月1日 · Task-based functional magnetic resonance imaging (fMRI) has been used to examine neuroanatomical and functional changes following mild traumatic brain injury (mTBI). Prior studies have lacked consistency in identifying common regions of altered neural activity during cognitive tasks.

2012年7月31日 · Resting-state fMRI studies have recently emerged as a useful tool for investigating brain functional connectivity after severe TBI 4,8-11 and in subjects with mild TBI examined during the early stages. 12,13 These studies provide information about brain activity and connectivity in the absence of task performance, a condition that allows ...

2015年2月1日 · Functional magnetic resonance imaging (fMRI) offers great promise for elucidating the neuropathology associated with a single or repetitive mild traumatic brain injury (mTBI). The current review discusses the physiological underpinnings of the blood-oxygen level dependent response and how trauma affects the signal.

2018年3月1日 · Arenth等采用fMRI对TBI患者进行检测，结果发现当予以患者听觉、触觉及视觉等刺激时，BOLD-fMRI显示相应皮层出现明显的激活 ；Aslaksen等研究发现fMRI检查下发现的TBI患者脑白质微细结构病灶与患者认知障碍有相关性，而常规CT、MRI检查下则显示微细病灶与其无关 ...