VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for ...
2023年6月23日 · Mechanistically, VANGL2 interacted with TBK1 and promoted the selective autophagic degradation of TBK1 via K48-linked polyubiquitination at Lys 372 by the E3 ligase …
TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery
2024年6月25日 · TRIM5α mediates K63-linked ubiquitination of TBK1. These ubiquitin chains scaffold the formation of a multi-protein complex that favors TBK1 activation on damaged …
NBR1 mediates autophagic degradation of IRF3 to negatively …
2022年10月1日 · Autophagy negatively regulates type I IFN synthesis by degradation of IRF3. NBR1 as cargo receptor in IRF3 degradation and binds IRF3 via the UBA domain. Deficiency …
Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 …
Our data collectively define enteric CoV nsp2 as a novel virulence determinant, propose a crucial role of nsp2 in diminishing innate antiviral immunity by targeting TBK1 for NBR1-mediated …
The EMBO Journal|Optineurin为TBK1的激活提供自噬接触位点
本篇研究中， 研究者发现发现自噬衔接蛋白Optineurin (OPTN)为TBK1激活提供了一个独特的平台。 TBK1敲除抑制了OPTN而不是NDP52在自噬体形成位点的定位，而敲除OPTN抑制TBK1的 …
Opposing regulation of the STING pathway in hepatic stellate cells …
2024年10月17日 · Nishimura et al. demonstrate that NBR1 is a synthetic vulnerability of p62 deficiency in HSCs by opposingly regulating the STING-interferon cascade. NBR1 ablation …
Adaptor‐Mediated Trafficking of Tank Binding Kinase 1 During …
2025年3月6日 · TBK1 is recruited to ubiquitinated cargo by its direct or indirect binding of autophagy adaptors like p62, OPTN, NBR1, TAX1BP1, and NDP52 [4, 7-9, 12, 16, 18]. This …
TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery
2024年6月25日 · Here, we show that K63-linked polyubiquitination of the key mitophagy regulator TBK1 is essential for its mitophagy functions. This modification is catalyzed by the ubiquitin …
Autophagy inhibition dysregulates TBK1 signaling and promotes ...
Using a mouse model of cerulein-induced pancreatitis, we found that loss of autophagy by deletion of Atg5 enhanced activation of the IκB kinase (IKK) related kinase TBK1 in vivo, …
Phosphorylation of OPTN by TBK1 enhances its binding to Ub ... - PNAS
2016年3月30日 · By using quantitative proteomics, we show that Tank-binding kinase 1 (TBK1) phosphorylates all four receptors on several autophagy-relevant sites, including the ubiquitin- …