2021年4月12日 · We report a mechanism by which mtp53 suppresses both cell-autonomous and non-cell-autonomous signaling to promote cancer cell survival and evasion of tumor immune surveillance. Mtp53 interferes with the function of the cytoplasmic DNA sensing machinery, cGAS-STING-TBK1-IRF3, that activates the innate immune response.

2021年4月12日 · We report a mechanism by which mtp53 suppresses both cell-autonomous and non-cell-autonomous signaling to promote cancer cell survival and evasion of tumor immune surveillance. Mtp53 interferes with the function of the cytoplasmic DNA sensing machinery, cGAS-STING-TBK1-IRF3, that activates the innate immune response.

2023年3月1日 · Mutant p53 binds directly to TBK1, prevents TBK1 from forming a ternary complex with STING and IRF3, and ultimately inhibits the activation of the cGAS-STING pathway. 223 Mutant p53 helps...

2021年2月7日 · 进一步地实验发现，mtp53阻碍了sting/tbk1/irf3通路激活后irf3的核定位，并且mtp53可抑制ht-dna诱导的依赖于irf3的细胞凋亡，由此表明对于p53突变的细胞而言，其无法对cgas/sting/tbk1/irf3通路的激活产生细胞固有的反应。

In this work, we sought to determine the role of p53 in antiviral immunity by employing both genetic and pharmacological approaches. We found that p53 has a protective effect on the innate immune response to VSV infection through MAVS-TRAF3-TBK1 signaling. Loss of p53 robustly suppresses IFN-β production and causes increased VSV burden in mice.

2023年1月19日 · We engineered p53 null 4T1 breast cancer cell line to inducibly express WTp53 and we observed that WTp53 expression increased TBK1 substrate phosphorylation (Figure 1C). Moreover, p53 knockdown with two different shRNAs reduced TBK1 substrate phosphorylation in CT26 murine colorectal cancer cells (Figure 1D). Our data indicate that WTp53 ...

2021年2月8日 · 结果发现， 果然是突变的p53阻断了cgas/sting/tbk1/irf3这条先天性免疫信号通路。 只要抑制突变 TP53 基因的表达，跑最后一棒的IRF3就能被激活；只要突变的 TP53 基因过表达，IRF3就完蛋。

2023年11月8日 · Total RNA sequencing analysis identified the correlation of p53 R211* with immune-related pathways. Further mechanistic studies revealed that p53 R213*/R211* instead of wild-type p53 interacted with TANK-binding kinase 1 (TBK1) and suppressed the innate immune TBK1-Interferon regulatory factor 3 (IRF3)-Stimulator of interferon genes (STING ...

2021年2月6日 · 进一步的实验发现，mtp53阻碍了sting/tbk1/irf3通路激活后irf3的核定位，并且mtp53可抑制ht-dna诱导的依赖于irf3的细胞凋亡，由此表明对于p53突变的细胞而言，其无法对cgas/sting/tbk1/irf3通路的激活产生细胞固有的反应。

2020年4月13日 · During translocation, cGAMP recruits TANK-binding kinase-1 (TBK1), which phosphorylates STING, leading to recruitment of interferon regulatory factor-3 (IRF3) 5. TBK1 phosphorylates IRF3,...