2019年5月22日 · Here we show that a conserved PLPLRT/SD motif within the C-terminal tail of STING mediates the recruitment and activation of TBK1. Crystal structures of TBK1 bound to STING reveal that the...

根据晶体结构，研究人员设计了多个TBK1的突变体，用 CRISPR-Cas9技术 制备了TBK1敲除细胞，研究了这些突变体的功能发现，参与和STING结合的残基一旦突变，就会影响STING信号传递通路的激活. 5. 研究人员还通过冷冻电子显微技术发现cGAMP第二信使分子可以诱导全长STING分子多聚体的形成，这也可能是激活TBK1 所必须的步骤。 总之， 本文在分子和细胞层次系统深入地研究TBK1如何被STING活化的分子机理，对于免疫学具有重要贡献。 另外，该研究还揭示了有 …

2020年12月1日 · The cGAS‒STING‒TBK1 axis is initially recognized as the essential mechanism for the host to defeat bacteria and virus invasions, and is now believed as the major innate immune pathway implicated in the generation of spontaneous anti-tumor T cell response by sensing tumor-derived dsDNA.

2023年9月18日 · TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against...

2019年3月6日 · The cryo-electron microscopy structure of human TBK1 in complex with cyclic GMP–AMP-bound chicken STING reveals a binding mode that suggests that STING phosphorylation by TBK1 requires ...

2023年9月18日 · TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. TBK1, and its homologue IκB kinase-ε (IKKε), can also induce pro-inflammatory responses that contribute to pathogen clearance.

2019 年 5 月 23 日，来自德州农工大学（ Texas A&M University）的李平伟教授团队在《自然》杂志上在线发表了一篇最新研究论文：A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1，揭示了 STING 蛋白 C 末端上 PLPLRT/SD 基序介导 TBK1 的招募和激活，有望为 ...

For the first time, we demonstrate by SPR assays that TBK1, a critical component in IFN-I production pathway, binds directly to ZIKV NS4B (KD of 3.7 × 10^-6 M).

Among the PRRs that initiate proinflammatory cytokine transcription, TANK-binding kinase 1 (TBK1) is a critical kinase and a central node within the signaling network.

2020年7月10日 · TANK-binding kinase 1 (TBK1), along with its close analogue I-kappa-B kinase epsilon, is a central kinase in innate adaptor complexes linking activation of PRRs to mobilization of transcriptional factors that transcribe proinflammatory cytokines, type I interferon (IFN-α/β), and myriads interferon stimulated genes.