What is a cardiac PYP scan? Cardiac means related to the heart. PYP stands for pyrophosphate. A cardiac PYP scan uses a radioactive form of PYP called Tc99m-PYP. Why is the scan done? This scan can be used to find out if you have a rare disease called cardiac amyloidosis (am-uh-loi-DO-sis). It can also tell: • What form of amyloidosis you have.

2023年3月24日 · 对于99mTc-PYP 1分、单克隆免疫球蛋白阴性的患者，建议通过SPECT或SPECT/CT图像，以区分血池摄取或心肌摄取。 结合CMR检查（LGE、T1maping和ECV）、ECG、超声心动和临床症状，如怀疑ATTR-CM建议通过活检（首先心肌）确诊。 对活检阴性或未活检的患者，建议在6个月-1年后进行99mTc-PYP显像随访。

• A distinct advantage of 99mTc-PYP imaging, even when echocardiography and CMR are diagnostic for cardiac amyloidoisis, is its ability to specifically identify ATTR cardiac amyloidosis non-invasively

2024年12月22日 · 99mTc-PYP诊断ATTR-CA原理. 99mTc磷酸盐衍生物最早在核医学显像中主要用于进行骨显像及急性心梗显像。上世纪80年代初，有病例报告显示CA患者的心脏对99mTc-焦磷酸盐（99mTc-PYP）有独特的摄取模式，当与其他无创检查结果相结合时有助于CA的诊断[4]。

2022年6月3日 · 随着99tcm-pyp心肌核素显像技术的深入开展，核医学为attr-cm患者提供了一种除心内膜心肌活检以外的无创性诊断方式，能够更加高效和准确地诊断attr-cm。

99m Tc‐PYP scintigraphy can be considered with a high priority when a patient presents with an elevated level (≥0.0308 ng/mL) of hs‐cTnT, increased left ventricular posterior wall thickness (≥13.6 mm), and wide QRS (≥120 ms); the 99m Tc‐PYP positivity rates were 96%, 63%, 21%, and 13% when 3, 2, 1, and no criteria were met ...

TechnescanTM PYPTM (Kit for the Preparation of Technetium Tc 99m Pyrophosphate Injection) is a sterile, non-pyrogenic, diagnostic radiopharmaceutical suitable for intravenous administration after...

• Myocardial 99mTc-PYP uptake patterns are categorized as absent, focal, diffuse or focal on diffuse. • Scans with focal 99m Tc-PYP uptake could represent rib

转甲状腺素蛋白相关淀粉样心肌病 (transthyretin-related amyloid cardiomyopathy，ATTR-CM)是由于转甲状腺素前体蛋白错误折叠形成的不溶性淀粉样纤维沉积于心肌细胞间隙所致的病变。 该病变可导致心肌功能障碍、充血性心力衰竭和死亡。 若能对该病变进行早期临床明确诊断，可以尽早对病患使用药物治疗，干预病情进展，从而有效改善患者预后。

2022年4月1日 · 骨扫描和心肌梗塞放射性示踪剂99mTc-焦磷酸盐(pyrophosphate，PYP)可用于检测ATTR，属于旧放射性示踪剂的新应用，诊断的的敏感性> 99%和特异性约86%[1]。使用99mTc-PYP核素显像阳性(心肌摄取2或3级)可以准确诊断ATTR-CM。