Lipid Metabolism - PMC
Lipid synthesis requires the glycolytic intermediate dihydroxyacetone phosphate and TCA cycle intermediate citrate to generate glycerol 3-phosphate and acetyl-CoA, respectively. Fatty acid …
Mitochondrial TCA cycle metabolites control physiology and …
2020年1月3日 · Recent evidence confers a new role for TCA cycle intermediates, generally thought to be important for biosynthetic purposes, as signaling molecules with functions …
Regulation and function of the mammalian tricarboxylic acid cycle
The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central metabolic pathway that performs the essential function of oxidizing nutrients to support cellular …
Elevated TCA cycle function in the pathology of diet-induced …
The tricarboxylic acid (TCA) cycle is the site of terminal fat oxidation, chief source of electrons for respiration, and a metabolic progenitor of gluconeogenesis. Therefore, we tested whether …
Lipid metabolism in T cell signaling and function - Nature
2022年4月28日 · Lipid metabolism has emerged as a key regulator of T cell responses, with selective lipid metabolites serving as metabolic rheostats to integrate environmental cues and …
Cell Metabolism：代谢流分析揭示TCA循环分解代谢的营养来源
2020年9月，杜克大学医学院等单位的相关研究人员在《Cell Metabolism》上发表了题为“Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle”的研究 …
TCAIM is linked to lipid metabolism - Nature
2025年3月11日 · It is encouraging that TCAIM suppression may enhance fatty acid oxidation, and identification of the direct effects of TCAIM on lipid metabolism is promising for developing it …
Lipids guide T cell antitumor immunity by shaping their metabolic …
2024年12月31日 · Lipids are key drivers of CD8+ T cell (CTL) activity acting as metabolic rheostats, with distinct species differentially modulating CTL fate and function. Lipids, as …
Imbalances in TCA, Short Fatty Acids and One-Carbon …
2022年2月25日 · In the metabolome, there is a clear disruption of the mitochondrial metabolism due to three key pathways in metabolism, which are β-oxidation of FAs, TCA cycle and 1C …
Simultaneous Measurement of Tricarboxylic Acid Cycle ... - PubMed
2020年3月12日 · The tricarboxylic acid (TCA) cycle is a central part of carbon and energy metabolism, also connecting to glycolysis, amino acid, and lipid metabolism. The quantitation …