Tricyclic antidepressants (TCAs) are a class of drug used to treat depression, OCD, bedwetting, migraines, tension headaches, premenstrual syndrome and more. Side effects may include blurred vision, dry mouth, constipation, weight gain or loss, low blood pressure on standing, rash, hives, and increased heart rate.

2023年4月17日 · Tricyclic antidepressants (often abbreviated to TCAs) are a group of medicines that all have a similar structure and all work in a similar way. They may be used for the treatment of other conditions, not only depression. Experts are …

2023年7月24日 · Tricyclic antidepressants (TCAs) are medications that are FDA-approved to treat symptoms of major depressive disorder. But healthcare providers more often prescribe them for other conditions, such as chronic pain and insomnia.

2024年6月14日 · Tricyclic antidepressants are used for depression (major depressive disorder, or MDD). Different TCAs can be used for various indications, and your doctor can go into more detail about the different uses for particular TCAs. TCAs are …

2023年8月17日 · Tricyclic antidepressants (TCAs) constitute a class of medications used to manage and treat major depressive disorder (MDD). These medications function by inhibiting the reuptake of neurotransmitters, such as serotonin and norepinephrine, which can modulate mood, attention, and pain in individuals.

2024年10月8日 · Tricyclic antidepressants are among the earliest antidepressants developed. They're effective, but they've generally been replaced by antidepressants that cause fewer side effects. Tricyclic antidepressants may be a good option for some people. In certain cases, they ease depression when other treatments have failed.

Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants. TCAs were discovered in the early 1950s and were marketed later in the decade. [1] . They are named after their chemical structure, which contains three rings of atoms.

2024年8月11日 · Tricyclic Antidepressants (TCAs) are named after their chemical structure, which contains three rings of atoms (“tricyclic ring system”). TCAs are most commonly used as antidepressants, but also have a role in the treatment of neuropathic pain, chronic pain, migraines, and headaches.

2018年9月2日 · Tricyclic or cyclic antidepressants (TCAs) are an early type of antidepressant. They are a good choice for those whose depression is resistant to other drugs,...

三环类抗抑郁药 (TcAs)是临床上治疗抑郁症最常用的药物之一，其核心结构是中间一个七元杂环两边连接一个苯环构成。 其中，丙米嗪是最早发现的具有抗抑郁作用的化合物，常用药物还有氯米帕明、阿米替林、多塞平等。 TCAs主要在肝脏代谢，参与的代谢酶有CYP1A2、CYP2D6、CYP3A4 等。 主要代谢为三环核氧化，如2位或10位碳原子羟化（CYP2D6催化）、脂肪侧链氧化、氮原子的去甲基化（CYP3A4催化）。 由于CYP的活性受多种因素的影响，血浆中活性代谢产物的浓 …