2024年11月30日 · The ECG is a vital tool in the prompt diagnosis of poisoning with sodium-channel blocking medications such as tricyclic antidepressants (TCA), which cause CNS and cardiovascular toxicity in overdose in the form of seizures and ventricular dysrhythmias.

Inhibition of presynaptic neurotransmitter reuptake (norepinephrine and serotonin) is the primary mechanism for the therapeutic effects of tricyclic antidepressants (TCAs). Following overdose, the following cellular effects often produce important clinical consequences: Blockade of cardiac fast sodium channels

2023年7月17日 · Despite the current limited use of TCAs, TCA-overdose-associated hospitalizations and fatalities are on the rise. This activity reviews the evaluation and management of tricyclic antidepressant toxicity and highlights the role of interprofessional team members in collaborating to provide well-coordinated care and enhance outcomes for affected ...

This is your one stop page for TCA overdose. Find out how to manage the acute overdose and the potential complications. We have also covered the basic TCA pharmacology and a tutorial about sodium channel blockade and the ECG, find out why the QRS will widen.

Tricyclic antidepressant overdose is poisoning caused by excessive medication of the tricyclic antidepressant (TCA) type. Symptoms may include elevated body temperature, blurred vision, dilated pupils, sleepiness, confusion, seizures, rapid heart rate, and cardiac arrest. [1] .

2022年5月7日 · The key clinical features of TCA overdose include signs of anticholinergic toxicity and the result of sodium channel blockade. Severe effects include arrhythmia, cardiovascular collapse, convulsions and coma.

2024年4月5日 · Tricyclic antidepressant overdose should be suspected in patients with a history of depression, suicidality, and overdose presenting with a sudden deterioration in mental status and vital signs. At 1 to 2 hours after ingestion, there is a rapid decline in mental and cardiovascular status.

三環類抗抑鬱藥藥物過量（英語： Tricyclic antidepressant overdose ），係指過度攝取三環類抗抑鬱藥（英語： tricyclic antidepressant ，簡稱 TCA）類型藥物而中毒。症狀有體溫過高、視線模糊、瞳孔放大、嗜睡、意識錯亂、癲癇發作、心跳過速及心搏停止 [1] 。

We conducted a systematic review to compare the toxicity of individual TCA in overdose and the risk of serious adverse cardiac events occurring with therapeutic doses.

2024年12月18日 · Tricyclic Antidepressants (TCA) are weak bases (pKa 8.5) that can cause life-threatening sodium channel toxicity leading to: anticholinergic effects; inhibition of catecholamine reuptake (initial increase in sympathetic tone -> prolonged decrease) profound alpha-adrenergic blockade; sodium channel blockade -> cardiotoxicity and CNS effects; HISTORY