2024年11月30日 · The ECG is a vital tool in the prompt diagnosis of poisoning with sodium-channel blocking medications such as tricyclic antidepressants (TCA), which cause CNS and …

Find out how to manage the acute overdose and the potential complications. We have also covered the basic TCA pharmacology and a tutorial about sodium channel blockade and the …

2018年3月22日 · What are the main ECG pointers for TCA overdose? Cardiac toxicity can develop quickly in TCA overdose, so get an ECG early in the clinical course if suspecting the …

2022年5月7日 · 12-lead ECG: TCA toxicity causes serious and potentially fatal arrhythmias. Typical ECG findings include widened QRS and prolonged QTc (Figure 1). Patients with an …

2009年9月26日 · Discuss the classic EKG findings of tricyclic antidepressant cardiotoxicity (TCA). Formulate an empiric treatment regimen based on EKG findings. Summarize the relevance of …

Specific myocardial effects of cardiotoxic drugs have well-described electrocardiographic manifestations. In the practice of clinical toxicology, classic ECG changes may hint at …

2008年1月24日 · Patients presenting TCA overdose should be treated with great care and a high index of suspicion, particularly if the symptoms are progressive. Challenging EKG and 12-lead …

2024年1月12日 · Tricyclic antidepressants (TCAs) overdoses are Australia’s major cause of drug ingestion fatality. TCAs are weak bases (typically with pKa of ~8.5) that act as noradrenaline …

2020年6月2日 · TCA overdose and the resultant sodium channel and potassium channel blockade can result in QRS and QT prolongation respectively. In severe cases of overdose, …

The tricyclic antidepressant (TCA) agents are recognized for their potentially lethal cardiovascular and neurological effects in poisoned patients. The 12-lead electrocardiogram (ECG) has …