Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans, is encoded by the TCF7L2 gene. [5] [6] The TCF7L2 gene is located on chromosome 10q25.2–q25.3, contains 19 exons.

2024年12月25日 · TCF7L2 (Transcription Factor 7 Like 2) is a Protein Coding gene. Diseases associated with TCF7L2 include Type 2 Diabetes Mellitus and Autism. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

该基因编码含有高迁移率基团 (HMG) 盒的转录因子，该转录因子在 Wnt 信号通路中起着关键作用。 该蛋白质与血糖稳态有关。 该基因的遗传变异与 2 型糖尿病风险增加有关。 已发现该基因编码多种不同亚型的几种转录变体。 [RefSeq 提供，2010 年 10 月] This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis.

TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that forms a basic part of the Wnt signaling pathway. This gene has highly conserved sequence regions that …

TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR. TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes. Role of EPO and TCF7L2 Gene Polymorphism Contribution to the Occurrence of Diabetic Retinopathy.

TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that forms a basic part of the Wnt signaling pathway. This gene has highly conserved sequence regions that correspond to functional domains.

The TCF7L2 protein is a key transcriptional effector of the Wnt/β‐catenin signaling pathway, regulating gene expression. It was initially identified in cancer research and embryologic developmental studies. Later, the TCF7L2 gene was linked to type ...

The rapid elevation of TCF7L2 from mere candidate to presidential status (a rise enabled by the availability of large sample sets from diverse populations and rapid, accurate genotyping), has meant that years of debate about the validity of TCF7L2 as a diabetes-susceptibility gene have been avoided. As a result, the full panoply of biochemical ...

2025年2月8日 · Coronary artery disease patients with rs7904519 (TCF7L2) are at a persistent risk of type 2 diabetes. Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis.

2014年12月15日 · Using RNA-sequencing, we have identified a TCF7L2-regulated transcriptional network responsible for its effect on insulin secretion in rodent and human pancreatic islets. ISL1 is a primary target of TCF7L2 and regulates proinsulin production and processing via MAFA, PDX1, NKX6.1, PCSK1, PCSK2 and SLC30A8, thereby providing evidence for a ...