The aim of radiotherapy is to achieve a high probability of local tumor control (tumor control probability, TCP) at a low risk of normal tissue complications (normal tissue complication probability, NTCP). This paper gives a brief introduction into dose response relationships for early and late radiation responses and tumor control.

2022年2月2日 · This chapter introduces the concepts Tumour Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) in radiotherapy and signposts literature related to the use of machine learning in this field.

2019年8月1日 · In radiotherapy, Tumor Control Probability (TCP) is a parameter used to calculate the percentage of tumor killing, while its effect on normal tissue damage describe by Normal Tissue Complication Probability (NTCP). Both TCP and NTCP depend on fractionation and cell biological effects such as repopulation, repair, redistribution and re-oxygenation.

We have developed a convenient software tool for estimating the TCP or NTCP arising from differential (frequency) dose‐volume histograms (DDVHs). The program, TCP_NTCP_CALC, was designed to amalgamate relevant current radiobiological modeling knowledge and make it accessible to clinicians, treatment planners, and researchers.

Python code used to model the variation in TCP and NTCP with dose fraction specific dose variations. There is huge flexibility in variation of the delivered dose per fraction.

Radiotherapy treatment plan evaluation relies on an implicit estimation of the tumor control probability (TCP) and normal tissue complication probability (NTCP) arising from a given dose distribution. A potential application of radiobiological modeling to radiotherapy is the ranking of treatment pla …

2021年11月1日 · Calculation of tumor control probability (TCP) and normal tissue complication probability (NTCP) is becoming increasingly relevant for optimizing treatment strategies, for example the selection of patients for proton therapy.

2021年11月1日 · In this study, different methods of applying TCP and NTCP models to treatments with anatomical changes are developed and compared. These methods were evaluated on an example of locally advanced non-small cell lung cancer (NSCLC) patients using two extreme scenarios: no adaption vs online daily adaptive proton therapy (DAPT).

The aim of radiotherapy is to achieve a high probabil-ity of local tumor control (tumor control probability, TCP) at a low risk of normal tissue complications (normal tissue complication...

Radiation therapy is a double-edged sword which damages both tumor and normal cells. Achieving treatments with high tumor control probability (TCP) yet low normal tissue complication probability (NTCP) is often a struggle because we rarely have a unified understanding of the dosimetric and clinical …