T细胞是如何被激活的？ - 知乎 - 知乎专栏
CD28是以同二聚体形式表达在T细胞膜表面的44kD蛋白，是T细胞活化的主要共刺激分子受体家族，其受体为B7-1 (CD80)和B7-2（CD86），在激活的DC细胞和其他APC上表达；CD28家族 …
CD28-mediated co-stimulation: a quantitative support for TCR …
2003年12月1日 · CD28 potently enhances T-cell receptor (TCR)-induced proliferation and differentiation of naive T cells, especially at low TCR occupancy, making it responsible for the …
T细胞中的免疫检查点受体信号通路|CD28|ITSM|磷酸化|TCR|免疫
2022年8月31日 · CD28增强TCR驱动的酪氨酸磷酸化，并与磷脂酰肌醇3激酶（PI3K）和Grb2募集一起作用，分别触发Akt-mTor和Ras-MAPK途径。 淋巴细胞功能最具特征的负性调节受体 …
CD28 as a Molecular Amplifier Extending TCR Ligation and …
2000年12月26日 · Here we show that, by enhancing T cell/APC close contacts, CD28 facilitates TCR signal transduction. Moreover, the signal supplied by CD28 does not lead to increased …
CD28 Costimulation: From Mechanism to Therapy - Cell Press
CD28 ligation leads to unique epigenetic, transcriptional, and post-translational changes in T cells that cannot be recapitulated by TCR ligation alone. We discuss the function of CD28 and its …
T cell costimulatory receptor CD28 is a primary target for PD-1
2017年3月9日 · Using total internal reflection fluorescence (TIRF) microscopy and a supported lipid bilayer functionalized with an ovalbumin peptide–MHC class I complex (pMHC; TCR …
T-cell regulation by CD28 and CTLA-4 - Nature
2001年12月1日 · CD28 crosslinking reduces the number of TCRs that need to be engaged, as well as the time required for T cells to interact with antigen, and enhances the magnitude of …
许琛琦研究组合作研究揭示T细胞共刺激受体CD28的活性调控机制
2017年10月25日 · tcr-ca 2+-cd28 的正反馈环路模型. 在静息状态下，带负电荷的酸性磷脂可以屏蔽tcr和cd28的活性位点；生理条件下，抗原的数量非常微量，抗原对tcr的初始激活可以诱 …
Cutting Edge: The Related Molecules CD28 and Inducible …
2001年1月1日 · T cell proliferation, differentiation, peripheral deletion, and anergy are regulated by signals delivered through not only the TCR, but also through cytokines and costimulatory …
TCR and CD28 activate the transcription factor NF-κB in T-cells …
2015年1月1日 · In this paper, using primary T-cells from various knock-out (Cd28 −/−, adap −/−) and knock-in (i.e. Cd28 Y-170F) mice in conjunction with transfected Jurkat T-cells, we show …