TCR CD3: Structure, Function, and Signal Pathways
Mar 12, 2025 · The TCR CD3 complex is a multi-subunit structure that facilitates antigen recognition and intracellular signaling in T cells. It consists of the antigen-binding TCR heterodimer, typically composed of α and β chains, and the CD3 signaling subunits: CD3γ, CD3δ, CD3ε, and the ζ-chain homodimer.
Structural basis of assembly of the human T cell receptor–CD3 …
Aug 28, 2019 · In this study, we report a cryo-electron microscopy (cryo-EM) structure of a human TCR–CD3 complex in its unliganded state at 3.7 Å resolution. The structure reveals the mechanisms that underlie...
T cell receptor (TCR) signaling in health and disease
Dec 13, 2021 · CD3 chains contain 10 ITAMs distributed in different CD3 molecules. The variable region (V) of TCR heterodimers recognize the antigen peptide-loaded on MHC (pMHC).
T-cell receptor (TCR): structure, role and TCR-CD3 complex
Apr 19, 2020 · For signal transduction TCR associates with CD3 molecule forming TCR-CD3 complex. The CD3 molecules participate in signal transduction after interaction of T-cell (TCR) with antigens. However CD3 does not influence interaction of antigen.
The structural basis of T-cell receptor (TCR) activation: An …
We review evidence from single-molecule and structural studies for force-induced conformational changes in the TCR–CD3 complex, for dynamically-driven TCR allostery, and for pMHC-induced structural changes in the transmembrane and cytoplasmic regions of CD3 subunits.
Modulating T Cell Responses by Targeting CD3 - PMC
The TCR/CD3 complex determines the specificity of the immune response and is the first signal needed to trigger T cell activation. The development of new approaches to modulate the activity of this complex is very attractive for immunotherapy.
Structures of human γδ T cell receptor–CD3 complex - Nature
Apr 24, 2024 · These findings reveal organizing principles of the γδ TCR–CD3 complex, providing insights into the unique properties of γδ TCR and facilitating immunotherapeutic interventions.
Molecular mechanisms for the assembly of the T cell receptor–CD3 ...
The T cell receptor (TCR)–CD3 complex represents on of the most intricate membrane receptor structures since it is built from six distinct chains. This complexity led to a number of different proposals for the arrangement of the receptor subunits, ...
The structural basis of T-cell receptor (TCR) activation: An ... - PubMed
Jan 24, 2020 · We review evidence from single-molecule and structural studies for force-induced conformational changes in the TCR-CD3 complex, for dynamically-driven TCR allostery, and for pMHC-induced structural changes in the transmembrane and cytoplasmic regions of …
The Organizing Principle in the Formation of the T Cell Receptor-CD3 …
Dec 27, 2002 · The T cell receptor-CD3 complex (TCR-CD3) serves a critical role in the differentiation, survival, and function of T cells, and receptor triggering elicits a complex set of biological responses that serve to protect the organism from infectious agents.
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