2021年5月15日 · SLP-76 binds the Tec-family tyrosine kinase, Itk, which phosphorylates SLP-76 Y173 and PLC-γ1 Y783. In this study, we identified TCR-inducible, Itk-mediated phosphorylation of Gads Y45 in a human T cell line and in mouse primary T cells.

2021年8月20日 · IL-2-inducible T cell kinase (ITK) is essential for proximal T cell receptor (TCR) signaling. Following TCR ligation, ITK is recruited to the cell membrane where it interacts with Linker for activation of T cells (LAT) and SH2-domain-containing leukocyte protein of 76 kDa (SLP76) (Qi et al., 2006; Bunnell et al., 2000).

T细胞受体(T cell receptor，TCR)是T细胞特异性识别和结合抗原肽-MHC分子的分子结构， 其介导的T细胞活化在胸腺T细胞发育, T细胞亚群分化以及效应T细胞功能发挥过程中均起着至关重要的作用。

2021年8月27日 · In order to help fight off pathogens and malignancies, CD8 + T lymphocytes send signals from the T cell receptor (TCR) through multiple transcription factor pathways. The strength of the TCR signal is modulated in part by the Tec kinase ITK, whose activity helps create graded amounts of T cell activation genes.

2023年4月20日 · Interleukin (IL)-2-inducible T cell kinase (ITK), a TEC-family kinase, is essential for T cell receptor (TCR) signaling. ITK functions as a tuning dial to translate variations in TCR signal strength into differential programs of gene expression.

2017年6月21日 · Here we show that ITK, an important modulator of TCR signalling, is required for the TCR-induced development of Tr1 cells in various organs, and in the mucosal system during parasitic and...

In T cells, the predominant Tec kinase is Itk, which functions downstream of the T-cell receptor to regulate phospholipase C-γ. This review highlights recent advances in our understanding of Itk kinase structure and enzymatic regulation, focusing on Itk protein domain interactions and mechanisms of substrate recognition.

2005年4月1日 · TEC-family kinases have a central role in the propagation of the signal induced by engagement of the T-cell receptor (TCR). ITK (interleukin-2-inducible T-cell kinase) forms a complex with...

2021年9月13日 · 在t细胞中，itk能够正向调节tcr信号通路，诱导il-2、il-4和il-13的生成。 当肽-MHC与同源TCR结合时，ITK能够被酪氨酸蛋白激酶LCK直接磷酸化，随后进行自磷酸化。

ITK is a Tec family non-receptor tyrosine kinase that plays multiple roles downstream of the TCR signaling. During the TCR signaling, ITK forms a complex with the adaptor molecule Slp-76, and is involved in the phosphorylation of PLC-γ and intracellular Ca 2+ mobilization.