TCR sequencing enables accurate and reproducible estimation of the relative frequency of different TCRs in blood or tissue, defined as the ‘TCR repertoire’. Therefore, analysis of the TCR repertoire provides a window into the nature of the adaptive immune response for an individual.

There are four key factors to consider when choosing a TCR-seq method: reproducibility, replicability, sensitivity, and specificity.

2 天之前 · This study reanalyzed previously published scRNA-seq and TCR-seq data to examine the proportion and characteristics of dual-TCR-expressing Treg cells in mice, presenting some useful insights into TCR diversity and immune regulation.

2021年1月8日 · T cells and the T-cell receptor (TCR) repertoire play pivotal roles in immune response and immunotherapy. TCR sequencing (TCR-Seq) technology has enabled accurate profiling TCR repertoire and currently a large number of TCR-Seq data are available in public.

2024年12月1日 · Bulk T cell repertoire sequencing (TCR-Seq) has emerged as a powerful method to profile the T cell repertoire of a sample in a high throughput fashion. Given the increasing utilization of TCR-Seq, we aimed here to provide a comprehensive, up-to-date review of the method, its extensions, and its ability to investigate chronic and autoimmune ...

Recent studies have developed high-throughput sequencing technologies to identify TCR sequences, analyze their antigen specificities using experimental and computational tools, and pair TCRs with transcriptional and epigenetic cell state phenotypes in single cells.

2021年7月19日 · Recent studies have developed high-throughput sequencing technologies to identify TCR sequences, analyze their antigen specificities using experimental and …

2023年11月16日 · We present spatially resolved T cell receptor sequencing (SPTCR-seq), which integrates optimized target enrichment and long-read sequencing for highly sensitive TCR sequencing. The SPTCR...

Database now incorporate the TCR-Seq data of γδ T cell. Faster and more flex way to download data. Our extensive database encompasses a wide range of cancer-related data, providing …

2025年3月12日 · TCR sequencing involves key steps to ensure accurate analysis of T-cell receptor repertoires, including sample collection, amplification, and sequencing library preparation.