Terminal deoxynucleotidyl transferase (TdT), also known as DNA nucleotidylexotransferase (DNTT) or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells.

TUNEL（Terminal Deoxynucleotidyl Transferase-Mediated dUTP Nick End Labeling）染色，即末端脱氧核苷酸转移酶介导的dUTP缺口末端标记法，是一种用于检测细胞凋亡中DNA片段化的常用技术。

Terminal deoxynucleotidyl transferase (TdT) is a nuclear enzyme that adds individual nucleotides to the termini of DNA strands without the use of a DNA template. TdT is expressed normally in cortical thymocytes, immature hematopoietic stem cells, and B and T lymphoblasts.

Terminal deoxynucleotidyl transferase (TdT) is a nuclear protein widely used as a marker for the diagnosis and classification of acute leukemia. The usual methods for detecting TdT require smears, imprints, or cryostat sections of unfixed tissue.

2025年3月1日 · Terminal deoxynucleotidyl transferase (TdT), a unique DNA polymerase, can elongate DNA by adding deoxynucleotides to the 3′ terminal of a DNA chain in a template-independent manner. Owing to their remarkable DNA synthesis activity, TdTs have promoted the development of numerous nucleic acid-based methods, tools, and associated applications ...

Terminal deoxynucleotidyl transferase (TdT) represents a useful marker for the diagnosis of acute lymphoblastic leukemia and lymphoblastic lymphoma. It is usually assayed in fresh tissue or cell suspensions by enzyme analysis, immunofluorescence, or immunoperoxidase.

Terminal deoxynucleotidyl transferase (TdT), although traditionally considered to be a marker of immature lymphoid cells, is now known to be a marker of hematopoietic immaturity in both lymphoid and myeloid lineages, correlating with CD34 expression and a poorer prognosis .

2024年12月2日 · Terminal deoxynucleotidyl transferase (TdT) is a nuclear enzyme that adds individual nucleotides to the termini of DNA strands without the use of a DNA template. TdT is expressed normally in cortical thymocytes, immature hematopoietic stem cells, and B and T …

1979年12月1日 · Terminal deoxynucleotidyl transferase (TdT) is an intracellular protein characteristic of certain primitive lymphocytes in normal thymus and bone marrow. It can be detected by enzyme assay or immunocytochemical staining. High levels of enzyme and increased numbers of TdT + cells are found in some lymphoblastic leukemias and lymphomas. Analysis ...

TdT is present in immature but not mature lymphocytes. TdT is not normally seen in peripheral blood lymphocytes but is positive in 1% to 2% of normal bone marrow lymphocytes. Strong TdT reactivity is found in 90% to 95% of acute lymphocytic leukemias and lymphoblastic lymphomas.