Tet methylcytosine dioxygenase 3 is a protein that in humans is encoded by the TET3 gene. [5] Tet3 and its respective protein TET 3 are members of the TET (ten-eleven-translocation) family of genes and proteins that play a role in DNA demethylation. [6] . DNA demethylation is the removal of suppressive methyl groups from the cytosine of DNA. [6] .

2024年12月25日 · TET3 (Tet Methylcytosine Dioxygenase 3) is a Protein Coding gene. Diseases associated with TET3 include Beck-Fahrner Syndrome and Non-Specific Syndromic Intellectual Disability. Among its related pathways are RNA Polymerase I Promoter Opening and Gene expression (Transcription).

2011年9月4日 · Here we report that, within mouse zygotes, oxidation of 5-methylcytosine (5mC) occurs on the paternal genome, changing 5mC into 5-hydroxymethylcytosine (5hmC). Furthermore, we demonstrate that the...

2023年8月11日 · Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3, can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield...

The ten–eleven translocation (TET) family of dioxygenases consists of three members, TET1, TET2, and TET3. All three TET enzymes have Fe+2 and α-ketoglutarate (α-KG)-dependent dioxygenase activities, catalyzing the 1st step of DNA demethylation by ...

The TET3 gene encodes a methylcytosine dioxygenase that initiates DNA demethylation to regulate gene expression during early zygote formation, embryogenesis, and neuronal differentiation (summary by Beck et al., 2020).

2024年11月18日 · To define TET3 function in cell differentiation, we have profiled the intestinal epithelium at single-cell level from wild-type and Tet3 knockout mice. We have found that Tet3 is mostly expressed in differentiated enterocytes.

2025年2月8日 · TET3 is a direct target gene of miR-27a-5p, and induces hypomethylation of CpG sites causing overexpression of Synaptophysin (SYP). The miR-27a-5p - TET3 - SYP signaling pathway may regulate proliferation and cortisol secretion in H295R cells and thus play a key role in the development of cortisol-producing adenoma.

2021年11月8日 · TET3 deficiency, or Beck-Fahrner syndrome (BEFAHRS; MIM: 618798), is a recently described neurodevelopmental disorder of the DNA demethylation machinery with a nonspecific phenotype resembling...

2015年4月14日 · We propose a mechanism for transcriptional activation in neurons that involves REST-guided targeting of TET3 to the DNA for directed 5hmC generation and NSD3-mediated H3K36 trimethylation.