2024年9月26日 · Here we show that iron oxide hydroxide nanocomposites can successfully mask TEV surfaces and unblock phagocytosis without affecting extracellular vesicles’ elicited immune goals. After...

2025年2月12日 · Ma et al. found that tumor-derived extracellular vesicles (tEVs) that contain PD-L1 drive cellular senescence and immune suppression in both human and mouse T cells. This was linked to altered lipid metabolism and cAMP …

2024年10月30日 · Based on their excellent tumor tropism ability, tumor-derived extracellular vesicles (TEVs) recently emerged as promising and excellent vectors for delivering agents (therapeutic nucleic acid, proteins, and small molecules) to tumor sites. (18,19) Furthermore, engineered TEVs could carry tumor antigens and deliver them to DCs and prevent ...

2024年3月15日 · Tumor-derived small extracellular vesicles (TEVs) play a pivotal role in cancer progression by transferring functional biomolecules between the parental and recipient cells. Here, we present a protocol to isolate TEVs directly from murine primary mammary tumor using differential centrifugation.

Background Tumor cell-derived extracellular vesicles (tEVs) have garnered significant attention as promising antigen delivery vehicles for the development of cancer vaccines....

2022年8月1日 · Here we show that TEVs can transfer activated TβRII to immune cells and pre-malignant tumor cells, thereby triggering host cell SMAD activation and resulting in defective anti-tumor immunity and...

Tumor-derived small extracellular vesicles (TEVs) play a pivotal role in cancer progression by transferring functional biomolecules between the parental and recipient cells.

2024年4月19日 · We performed an analysis of TEVs level in 50 healthy individuals, 148 benign individuals, and 219 newly diagnosed breast cancer patients for diagnosis. We found that the level of TEVs in patients with newly diagnosed breast cancer was higher than that in healthy and benign individuals (mean, TEVs: 3.83 U/μL vs. 3.40 U/μL, p < 0.0001, Figure 2 A).

2025年3月6日 · The clinical use of conventional medications for inflammatory bowel disease (IBD) is often limited by significant side effects. The extracellular vesicles derived from plant-based diets have shown promise in mitigating disease. Here, we discovered that natural extracellular vesicles from tea (TEVs) can achieve an appropriate transition from proinflammatory (M1) to anti-inflammatory (M2 ...

2021年4月1日 · TEM techniques, used in combination with immuno-labelling, have made significant contributions to the EV field as they couple information on morphology and size distribution to information on biochemical composition …