Transferrin’ across the blood–brain barrier - Nature
2020年6月5日 · Approaches that exploit TfR to enable proteins to cross the BBB through receptor-mediated transcytosis (RMT) have previously been investigated using constructs …
A shorter linker in the bispecific antibody RmAb158-scFv8D3
2024年12月23日 · Transferrin Receptor (TfR)-mediated transcytosis across the blood-brain barrier (BBB) enables the uptake of bispecific therapeutic antibodies into the brain. At …
Engineering antibody and protein therapeutics to cross the …
TfR-based BBB-crossing antibody carriers are often used to deliver three types of cargos: enzymes, recombinant proteins, and therapeutic antibodies. In each category, we discuss …
Transferrin Receptor-Mediated Uptake at the Blood-Brain ... - PubMed
2019年2月4日 · The transferrin receptor (TfR) is highly expressed by brain capillary endothelial cells (BCECs) forming the blood-brain barrier (BBB) and is therefore considered as a potential …
Age, dose, and binding to TfR on blood cells influence brain …
2023年5月11日 · The transferrin receptor (TfR) was the earliest described and still a widely used target for BBB-shuttles . In numerous preclinical studies, TfR has consistently shown high …
Strategies for delivering therapeutics across the blood–brain …
2021年3月1日 · Here we review recent developments and challenges related to selected blood–brain barrier-crossing strategies — with a focus on non-invasive approaches such as …
Blood-brain barrier transport using a high affinity, brain-selective ...
We established a functional selection method to identify high affinity single domain antibodies to the transferrin receptor 1 (TfR1) with efficient biotherapeutic delivery across the BBB.
Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and ...
2018年11月5日 · A monoclonal antibody (mAb) against the blood-brain barrier (BBB) transferrin receptor (TfR) is a potential agent for delivery of biologic drugs to the brain across the BBB. …
Therapeutic bispecific antibodies cross the blood-brain ... - Science
2014年11月5日 · Can TfR enhance antibody uptake in the primate brain? We describe two humanized TfR/BACE1 bispecific antibody variants. Using a human TfR knock-in mouse, we …
Design and uptake mechanism of the BBB shuttle. (A
Therapeutic antibodies have been re-engineered as BSAs that target the insulin receptor, TfR, or IGFR RMT systems at the BBB for the treatment of Alzheimer’s disease and Parkinson’s disease.