Transforming Growth Factor-β Signaling in Immunity and Cancer
2019年4月16日 · Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune …
TGF-β in Hepatic Stellate Cell Activation and Liver ... - PubMed
2019年11月11日 · Transforming growth factor (TGF)-β is a master profibrogenic cytokine and a promising target to treat fibrosis. However, TGF-β has broad biological functions and its …
TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer …
2019年6月5日 · TGF-β further supports cancer growth and progression by activating tumor angiogenesis and cancer-associated fibroblasts and enabling the tumor to evade inhibitory …
Blocking TGF-β Signaling To Enhance The Efficacy Of Immune …
Concurrent TGF-β blockade might be a feasible strategy to enhance the efficacy of immunotherapy and relieve ICI resistance. In this mini-review, we summarized the latest …
Endosomal signalling via exosome surface TGFβ‐1 - Shelke - 2019 ...
2019年9月20日 · Our results show that mast cell-derived exosomes are decorated with latent TGFβ-1 and are retained in recipient MSC endosomes, influencing recipient cell migratory …
雷帕霉素通过上调TGF-β/smad信号通路减轻小鼠的实验性自身免 …
2019年1月6日 · High-dose rapamycin obviously inhibited the production of IL-12, IFN-γ, IL-17 and IL-23 and induced the anti-inflammatory cytokines IL-10 and TGF-β. The percentage of Treg …
TGF-β/PI3K/AKT/mTOR/NF-kB pathway. Clinicopathological features in ...
2019年4月11日 · Our results suggest that TGFBR1 and PI3K could be used as useful biomarkers for early diagnosis and prognoses for biochemical recurrence in prostate cancer after radical …
The Role of the TGF-β Superfamily in Myocardial Infarction
In the infarcted heart, TGF-β isoforms modulate cardiomyocyte survival and hypertrophic responses, critically regulate immune cell function, activate fibroblasts, and stimulate a matrix …
Transforming Growth Factor-β Signaling in Immunity and Cancer
2019年4月16日 · Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune …
Specificity, versatility, and control of TGF-β family signaling
2019年2月26日 · Deregulation of TGF-β family signaling leads to developmental anomalies and disease, whereas enhanced TGF-β signaling contributes to cancer and fibrosis. Here, we …