In contrast to its favourable effects on Langerhans cell (LC) differentiation, transforming growth factor (TGF)-β1 has been reported to prevent dendritic cells from maturing in response to …

In this study, to further characterize the effects of TGF-β1 on LC function, we compared the response of TGF-β1-treated monocyte-derived DCs (MoDCs) with those of MoDCs exposed to …

转化生长因子-β（transforming growth factor-β, TGF -β）是属于一组新近发现的调节 细胞生长 和分化的TGF-β 超家族。 这一家族除TGF-β外，还有 活化素 （activins）、 抑制素 …

2024年3月22日 · Proper TGF-β signaling is critical to the normal functioning and homeostasis of healthy bodies while aberrant TGF-β signaling can lead to diseases of various categories.

In particular, strong evidence suggests that TGF-β1 is a relevant mediator of nociception and has protective effects against the development of chronic neuropathic pain by inhibiting the …

Defects of TGF- signaling, particularly in epithelial cells, tissue fibro- blasts, and immune cells, disrupt immune tolerance, promote inflammation, underlie the pathogenesis of fibrosis and …

Defects of TGF-β signaling, particularly in epithelial cells, tissue fibroblasts, and immune cells, disrupt immune tolerance, promote inflammation, underlie the pathogenesis of fibrosis and …

TGF-beta1 treatment, which augmented E-cadherin and down-regulated dendritic cell-specific ICAM3-grabbing non-integrin on MoDCs, significantly suppressed their CD86 expression and …

Elevated levels of SKI repress TGF-β signaling in the absence of inactivating mutations to the TGF-β signal transduction pathway, highlighting the importance of mutations in other …

tgf-β抑制自然杀伤（nk）和cd8 + ctl（细胞毒性t淋巴细胞）的功能，阻断“细胞毒性程序”关键蛋白，例如穿孔素，颗粒酶和细胞毒素。tgf-β诱导treg和th17细胞分化，并抑制b细胞增殖和iga分 …