In human, transforming growth factor β1 (TGF-β1) is considered central in the pathogenesis. Objectives: To investigate TGF-β1 pathway in IPF. Animals: Lung tissues from 12 affected and 11 control dogs. Serum from 16 affected West Highland white Terriers (WHWTs) and healthy dogs from predisposed (13 WHWTs, 12 Scottish Terriers and 13 Bichons ...

2014年10月20日 · Transforming growth factor β1 serum concentration was evaluated with the hypothesis that a high circulating concentration would be a marker of high TGF‐β1 lung activity in dogs with IPF and that it could be used as a biomarker. Surprisingly, no difference was seen between affected and healthy WHWTs, which precludes its use as a biomarker.

2021年6月14日 · In this study, we examined the potential of TGF-β1 as a therapeutic target in canine melanoma by confirming TGF-β1 production in melanoma cell lines and evaluating TGF-β1 serum concentrations in dogs with oral malignant melanoma (OMM).

2024年8月12日 · The transforming growth factor beta-1 (TGF-β1) plays a pivotal role in the progression of kidney fibrosis in humans (Meng et al. 2016), and its involvement in fibrotic processes across multiple organs has been demonstrated in dogs (Krafft et al. 2014; Spee et al. 2006; Tang et al. 2023).

Because fibrosis is a part of the alteration in the effected joints, we investigated the transforming growth factor beta 1 (TGF-β1) as an important regulation molecule of tissue fibrosis. We chose Osteoarthritis following a cruciate ligament rupture (CLR) because it is …

Osteoarthritis is a common problem in daily veterinary practice with insufficient knowledge about disease mechanism. Because fibrosis is a part of the alteration in the effected joints, we investigated the transforming growth factor beta 1 (TGF-β1) as an important regulation molecule of tissue fibrosis.

The epithelial-mesenchymal transition (EMT) is a crucial event that occurs during cancer metastasis and can be induced by transforming growth factor-β (TGF-β) in various tumor cells in vitro. However, little is known about the effects of TGF-β in canine mammary gland tumors (CMGTs). Here, we investi …

2013年12月5日 · The aim of this study was to evaluate TGF-b1 bio-chemical pathways in healthy dogs and dogs with IPF. Specifically, the concentration of circulating TGF-b1 was evaluated in addition to lung expression and localization of this molecule as well as proteins involved in its storage (LTBPs) and activation (amb6 and amb8 integrins and THBS1). We ...

2014年10月20日 · Transforming growth factor β1 serum concentration was evaluated with the hypothesis that a high circulating concentration would be a marker of high TGF-β1 lung activity in dogs with IPF and that it could be used as a biomarker. Surprisingly, no difference was seen between affected and healthy WHWTs, which precludes its use as a biomarker.

2013年2月4日 · Cerebrospinal fluid (CSF) and serum samples of dogs during the acute phase of SRMA (SRMA) were tested for IL-6, VEGF and TGF- β 1.