Role of TGF-β signaling pathway on Tenascin C protein ... - PubMed
We found a significant increase of TNC protein content in hippocampal homogenates after 1, 3, and 7 days of pilocarpine-caused SE, together with an enhancement of TNC immunoreactivity …
肌腱蛋白C(Tenascin C)在组织纤维化中的研究进展论文 - 豆丁网
机械压力直接调节TGF-pi的生物活性，TGF-日1与其Ⅱ型受体结 合激活细胞内连级信号瀑布，最终导致肌成纤维细胞的分化形成;同 时，TGF-pi上调了a-SMA和其它收缩性细胞骨架蛋白，增加 …
PDGF and TGF-β promote tenascin-C expression in subepithelial ...
2013年12月23日 · In this study, we examined how TnC modulated intestinal inflammation. Experimental Approach: Key Results: The pharmacological profiles of PDGF-BB and TGF-β in …
《爱求索》之细胞模型建立篇——TGF-β与细胞纤维化研究进展
2022年10月28日 · 转化生长因子-β（transforming growth factor-β, TGF-β），是一种多效性细胞因子，可以调节细胞生长、分化、ECM重构、内皮间质转化等。 目前已发现TGF-β家族存在5种 …
Negative regulation of lymphangiogenesis by Tenascin-C delays …
2025年2月21日 · Mechanistically, TNC facilitates integrin αvβ1 heterodimer formation, leading to the activation of non-canonical (TAK1/p38MAPK/ATF-2) TGFβ signaling to suppress …
PDGF and TGF-β promote tenascin-C expression in subepithelial ...
Key results: DSS-induced colitis in mice markedly increased TnC in the damaged mucosal areas and up-regulated mRNA for TnC, pro-inflammatory cytokines and growth factors (PDGF-B and …
Transcriptional regulation of tenascin genes - PMC
Transforming growth factor-β (TGF-β) plays an important role as inducer of extracellular matrix protein expression during development and in tissue regeneration. 73,74 Stimulation of TNC …
潜在的TGF-β激活是Tenascin家族的标志,Frontiers in Immunology
2021年4月16日 · 潜在的tgf-β在这种复合物中的细胞外激活是调节tgf-β活性以实现组织稳态和免疫细胞功能的关键步骤。 我们先前显示基质糖蛋白Tenascin-X（TN-X）与小的潜在TGF-β复合 …
Tenascin-C deficiency attenuates TGF-ß-mediated fibrosis …
Tenascin-C (TNC) is an extracellular matrix glycoprotein of unknown function that is highly expressed in adult lung parenchyma following acute lung injury (ALI). Here we report that mice …
Nanobodies targeting the tumor microenvironment and their …
2025年3月4日 · Tenascin-C (TNC) is a multimodular ECM glycoprotein that is highly expressed in cancer and chronic inflammatory diseases and has been considered as a promising target for …
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