TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand.

2016年3月11日 · Transforming Growth Factor alpha (TGF-α) is a protein structurally similar to Epidermal Growth Factor (EGF) and a ligand for EGF-receptors, competing with Epidermal Growth Factors. It has been found in a variety of non-neoplastic and neoplastic disorders where...

Transforming growth factor ([attribution needed], or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ. The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms .

2025年3月30日 · TGFA (Transforming Growth Factor Alpha) is a Protein Coding gene. Diseases associated with TGFA include Tooth Agenesis and Cleft Lip . Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway .

2020年12月21日 · Brissenden, J. E., Derynck, R., Francke, U. Transforming growth factor alpha gene (TGFA) maps to human chromosome 2 close to the breakpoint of the t(2;8) variant translocation in Burkitt lymphoma. (Abstract) Cytogenet.

2024年3月2日 · TGF alpha’s role in promoting cell growth is vital for tissue development and repair, whereas TGF beta’s functions in cell cycle regulation, immune response modulation, and maintenance of tissue homeostasis are indispensable.

1997年8月1日 · Transforming growth factor-α (TGF-α) exerts several effects on target cells, such as neovascularization promotion and mitogenic signalling. Using immunoelectron microscopy, we show that monocytes and neutrophils, store TGF-α in cytoplasmic granules.

Know comprehensive TGF-alpha protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

Transforming growth factor alpha (TGF-α) is a protein that in humans is encoded by the TGFA gene. [1] As a member of the epidermal growth factor (EGF) family, TGF-α is a mitogenic polypeptide. [2] The protein becomes activated when binding to receptors capable of protein kinase activity for cellular signaling.

TGF-alpha is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells.