The TGF-β Pathway: A Pharmacological Target in Hepatocellular …
Here we review the functions of TGF-β on HCC malignant and tumor microenvironment cells, and the current strategies targeting TGF-β signaling for cancer therapy. We also summarize the …
Immunomodulatory TGF-β Signaling in Hepatocellular Carcinoma
2019年11月1日 · This review dissects the genetic landscape of the TGF-β superfamily genes in HCC and discusses the essential effects of this pathway on the tumor immune …
The dichotomous role of TGF-β in controlling liver cancer cell survival ...
2020年9月20日 · TGF-β is able to induce the expression of EGF family ligands such as TGF-α and heparin-binding EGF (HB-EGF) in both normal hepatocytes and HCC cells, linking TGF-β …
Hepatology：癌症相关成纤维细胞通过CLCF1−CXCL6/TGF-β信号 …
癌症相关成纤维细胞 (Cancer-Associated Fibroblast)通过CLCF1−CXCL6/TGF-β信号轴介导肿瘤相关中性粒细胞、肿瘤细胞通讯交流来促进肝细胞癌进展。 这些结果可能支持CLCF1级联作为 …
Role of the Transforming Growth Factor-β in regulating ... - Nature
2017年10月2日 · We propose a new protumorigenic role for TGF-β in HCC cells: through decreasing mitochondrial respiration and enhancing glutamine anaplerosis and PPP cycle, …
Distinct functions of transforming growth factor-β signaling in c …
2021年2月19日 · In the present investigation, we investigated the expression of TGFβ signaling in c-MYC amplified human HCC samples as well as the mechanisms whereby TGFβ modulates …
【前沿进展】JBC & JMCB | 南昌大学严晓华团队揭示TGF-β …
近日，南昌大学基础医学院严晓华团队在国际生物化学期刊Journal of Biological Chemistry杂志上发表了题为“Upregulation of CYR61 by TGF-β and YAP signaling exerts a counter …
Dysregulated signaling in the transforming growth factor beta (TGF-b) pathway plays a central role in inflammation, fibrogenesis, and immunomodulation in the HCC microenvironment. This …
TGF-β signaling orchestrates cancer-associated fibroblasts in the …
2025年1月21日 · At the forefront of the tumor microenvironment (TME) orchestrating the initiation and advancement of HCC are cancer-associated fibroblasts (CAFs). TGF-β, widely …
Disruption of TGF-β signaling pathway is required to mediate …
2024年9月5日 · Transforming growth factor beta (TGF-β) is highly expressed in the liver tumor microenvironment and is known to inhibit immune cell activity. Here, we used human induced …