2022年12月22日 · For the canonical pathway, TGF-β ligands primarily bind to the TGF-β type III receptor (TGF-βRIII, also called betaglycan), which has a high expression level on many cell …

Type Ⅲ TGF-β receptor (TβRⅢ) is considered to be the coreceptor of TGF-β superfamily. TβRⅢ not only has an effect on classical Smad signaling pathway, but also on non-Smad signaling …

Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. …

Type III TGF-β receptor (TGFBR3) and its shed extracellular domain (sTGFBR3) regulate TGF-β signaling and maintain epithelial homeostasis, with loss of TGFBR3 expression promoting …

2013年8月8日 · Type III TGF-β receptor (TGFBR3) and its shed extracellular domain (sTGFBR3) regulate TGF-β signaling and maintain epithelial homeostasis, with loss of TGFBR3 …

Data indicate that TGF-beta2 (TGFB2) and TGF beta type III receptor (TGFBR3) are target genes of miR-193b in chondrogenesis. These data demonstrate that TbetaRIII regulates BMP …

Transforming growth factor beta (TGF-beta) superfamily ligands have important roles in regulating cellular homeostasis, embryonic development, differentiation, proliferation, immune …

Loss of expression of the TGF-β superfamily coreceptor, the type III TGF-β receptor (TβRIII or betaglycan), occurs in a broad spectrum of human cancers including breast, lung, ovarian, …

TGF-β isoforms signals through binding to three high-affinity cell surface receptors, the TGF-β type I (TβRI or ALK5), type II (TβRII) and type III (TβRIII or betaglycan) receptors. Upon ligand …

2010年7月13日 · Transforming growth factor-β (TGF-β) binds with two transmembrane serine/threonine kinase receptors, type II (TβRII) and type I receptors (TβRI), and one …