2023年3月1日 · In this study, we demonstrated that transforming growth factor-beta (TGFBI), an extracellular matrix (ECM) component, plays an important role in adipose metabolism and browning during high-fat...

2023年12月1日 · By inducing TGFBI loss-of-function in macrophage (MΦs) in vitro with siRNA and in vivo with Cre-Lox strategy in our developed TGFBI-floxed mice, we demonstrated disruption of TGFBI not only inhibited MΦ polarization to M2 phenotype and MΦ-mediated stimulation on PaC growth, but also significantly improved anti-tumor immunity, sensitizing PaC ...

2021年5月6日 · TGFBI knockout (KO) mice exhibited increased numbers of blood vessels in adipose tissue, and blood vessels from these mice showed enhanced infiltration into Matrigel containing Ad-CM....

In this study, we demonstrated that transforming growth factor-beta (TGFBI), an extracellular matrix (ECM) component, plays an important role in adipose metabolism and browning during high-fat...

Recombinant TGFBI and transgenic TGFBI overexpression can promote both islet survival and function. In this study, we generated TGFBI KO mice and further assessed TGFBI function and signaling pathways in islets. Islets from KO mice were of normal size and quantity, and these animals were normoglycemic.

2024年12月25日 · TGFBI (Transforming Growth Factor Beta Induced) is a Protein Coding gene. Diseases associated with TGFBI include Corneal Dystrophy, Groenouw Type I and Corneal Dystrophy, Reis-Bucklers Type. Among its related pathways are Metabolism of proteins and RNA Polymerase I Promoter Opening.

2024年2月23日 · TGFBI was significantly higher expressed in the platelet-treated ovarian cancer cells. An analysis of bioinformatics data revealed that increased expression of TGFBI led to significant decrease of overall survival (OS), progression-free survival (PFS) and post-progression survival (PPS) in ovarian cancer patients.

通过进行单细胞 RNA 测序，转化生长因子-β 诱导蛋白 (TGFBI) 被鉴定为小鼠 PaC 肿瘤中的 TAM 生成因子。 TAM 在人 PaC 中表达 TGFBI，并且 TGFBI 表达与人 PaC 生长呈正相关。

敲除Tgfbi基因exon 3，建立Tgfbi基因敲除小鼠模型。 *使用本品系发表的文献需注明: Tgfbi-KO mice (Cat. NO. 待定) were purchased from Shanghai Model Organisms Center, Inc..

2021年11月27日 · Our experiments demonstrated that TGFβRII KO CAR T-cells fully retained their capabilities in killing tumor antigen positive target cells and more intriguingly, could resist the anti-proliferative effect of exogenous TGFβ in vitro outperforming wild type CAR T-cells.