2024年12月25日 · TGFBR2 (Transforming Growth Factor Beta Receptor 2) is a Protein Coding gene. Diseases associated with TGFBR2 include Loeys-Dietz Syndrome 2 and Esophageal Cancer. Among its related pathways are Loss of Function of TGFBR2 in Cancer and TGF-beta receptor signaling activates SMADs.

Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene. It is a tumor suppressor gene. [5] This gene encodes a member of the serine/threonine protein kinase family and the TGFB receptor subfamily.

TGF-β的命名是根据这种细胞因子能使正常的成纤维细胞的表型发生转化，即在表皮生长因子（EGF）同时存在的条件下，改变成纤维细胞贴壁生长特性而获得在琼脂中生长的能力，并失去生长中密度信赖的抑制作用而来。 TGF-β信号在早期胚胎发育与组织器官形成、免疫监督、组织修复与成体稳态平衡中发挥重要作用。 TGF-β信号转导异常则可能导致多种疾病的发生，比如胚胎发育异常、肿瘤、组织纤维化、心血管疾病和免疫性疾病等。

该基因编码的蛋白质是一种跨膜蛋白，具有蛋白激酶结构域，与 TGF-β受体 1 型形成异二聚体复合物，并结合 TGF-β。 这种受体/配体复合物磷酸化蛋白质，然后进入细胞核并调节与细胞增殖 …

TGFBR2 forms an endocytic complex with PTH1R in response to PTH and regulates signalling by PTH and TGF-beta. TGFBR2 directly phosphorylates the PTH1R cytoplasmic domain, which modulates PTH-induced endocytosis of the PTH1R-TGFBR2 complex.

The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction.

2024年9月8日 · Go to complete Gene record for TGFBR2; Go to Variation Viewer for TGFBR2 variants; Summary. The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with …

2025年2月9日 · Integrative Network Analysis Combined with Quantitative Phosphoproteomics Reveals Transforming Growth Factor-beta Receptor type-2 (TGFBR2) as a Novel Regulator of Glioblastoma Stem Cell Properties. Narushima Y, et al .

Expression of the TGFBR2 gene, a putative tumor suppressor gene, is regulated by ETS transcription factors, of which FLI1 (193067) is one.

与人 tgfbr2（转化生长因子 β 受体 2）同源。 [由基因组资源联盟提供，2022 年 4 月] Enables SMAD binding activity; transforming growth factor beta binding activity; and transforming growth factor beta-activated receptor activity.