Using unbiased large-scale omics dissection, our bio-informatic analysis highlights thymidine kinase 1 (TK1) as an attractive target for HCC because of its highly positive correla-tion with malignant tumor behaviors, metabolic reprogramming, and poor prognosis.

既往研究显示，tk1可促进体外hcc细胞的增殖和迁移，为了评估tk1是否能促进hcc在体内的增殖能力，研究将tk1敲低的hep3b细胞、过表达tk1的yy8103细胞及其相应的对照hcc细胞接种到裸鼠中。

2023年6月6日 · Using a large-scale transcriptomic database and survival correlation screening, we identify thymidine kinase 1 (TK1) as a key driver. The progression of HCC is robustly mitigated by TK1 knockdown and significantly aggravated by its overexpression.

2024年9月29日 · In vitro experiments revealed an elevated expression of TK1 in HCC tissue and cell lines, and its role in influencing HCC cell proliferation by regulating G0/G1 phase arrest. Additionally, TK1 in cancer cells was found to potentially modulate Th2 cell polarization through the chemokine CCL5.

2023年6月6日 · Using a large-scale transcriptomic database and survival correlation screening, we identify thymidine kinase 1 (TK1) as a key driver. The progression of HCC is robustly mitigated by TK1 knockdown and significantly aggravated by its overexpression.

2024年3月4日 · 研究人员发现tk1可促进体外hcc细胞的增殖、迁移和侵袭，进一步通过建立小鼠模型，评价hcc细胞在体内的增殖能力。 通过观察小鼠肿瘤体积和重量、HE染色、免疫组化分析发现TK1敲低抑制了HCC细胞的增殖能力，提高凋亡率；TK1过表达可促进HCC细胞增殖，抑制细胞 ...

2023年11月30日 · Our findings argue that TK1 elevation directly increases HCC 1806 cell pathogenicity and is likely occurring by p21- and AKT3-mediated mechanisms to promote cell cycle arrest, cellular migration, and cellular survival.

该研究利用大规模转录组数据库和生存相关性筛选，作者确定胸苷激酶1 (tk1)是一个关键的驱动因素。tk1的下调可显著缓解hcc的进展，而tk1的过表达可显著加重hcc的进展。

A meta-analysis was conducted to evaluate the clinical significance of serum thymidine kinase 1 protein concentration (STK1p) in distinguishing between hepatocellular carcinomas (HCC) and non-HCC for predicting early progression and monitoring the response to transarterial chemoembolization in HCC.

2023年10月15日 · 该研究利用大规模转录组数据库和生存相关性筛选，作者确定胸苷激酶1 (tk1)是一个关键的驱动因素。tk1的下调可显著缓解hcc的进展，而tk1的过表达可显著加重hcc的进展。