2024年12月25日 · TLR2 (Toll Like Receptor 2) is a Protein Coding gene. Diseases associated with TLR2 include Leprosy 3 and Colorectal Cancer. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.

Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene. [5] TLR2 has also been designated as CD282 (cluster of differentiation 282). TLR2 is one of the toll-like receptors and plays a role in the immune system.

Numerous TLRs 2, 3, 4, 7, 8, and 9 have been identified as molecules of interest for the development of agonist, antagonist, and vaccines to develop a treatment strategy to control and prevent the development of CRC, which has a heavy bearing upon the TLR gene SNPs and the effects they have on immune modulation.

2016年10月16日 · The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and …

Gene ID: 7097, updated on 8-Feb-2025. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities.

TLR2 is one of the most studied pattern recognition receptors (PRRs) and is known to form heterodimers with either TLR1, TLR4, TLR6, and TLR10, allowing it to recognize a wide range of pathogens.

2016年9月14日 · The protein encoded by the TLR2 gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities.

这种蛋白质是一种细胞表面蛋白质，可以与其他TLR家族成员形成异源二聚体，以识别来自已知为病原相关分子模式（PAMPs）的微生物的保守分子。 PAMPs激活TLR导致信号通路上调，以调节宿主的炎症反应。 这个基因也被认为能响应细菌脂蛋白促进细胞凋亡。 这个基因与几种自身免疫疾病的病理学有关。 选择性剪接导致多个转录变异体。 [RefSeq，2016年1月提供] 当前研究发现，TLR2基因存在16种不同的转录本和16种不同的蛋白质变体。 Dir./Indir. Structural basis for …

Toll-like receptor (TLR) 2 is a member of the vertebrate protein family of TLRs that has been studied in substantial detail over the last years. The extracellular domain of the type I receptor molecule TLR2 contains 18 to 20 leucine rich repeat (LRR) and LRR like motives.

2025年2月19日 · We found that expression of the gene for TLR-2 is increased after Paracoccidioides brasiliensis infection in susceptible, but not resistant, mice. establish a proapoptotic signaling pathway for TLR2 and -4 in neurons that …