Physiological accumulation of lipid droplets in the newborn liver ...
Feb 1, 2025 · Finally, we investigated the role of Toll-like receptor 4 (TLR4) signaling in fat storage using knockout mice and cell-specific deletion strategies. Newborn mice displayed a …
Functional crosstalk between membrane lipids and TLR biology
Apr 1, 2016 · TLR4, the receptor for bacterial lipopolysaccharide (LPS), has been reported to signal from both plasma and endosomal membranes. Upon recognition, receptor signaling …
Factors Promoting Lipopolysaccharide Uptake by Synthetic Lipid Droplets
Feb 10, 2025 · LPS binds to a series of pattern recognition receptors, including toll-like receptor 4 (TLR4), and triggers an inflammatory response that produces pro-inflammatory cytokines. …
The upregulation of Annexin A2 by TLR4 pathway facilitates lipid ...
Jan 6, 2024 · Autophagic degradation of lipid droplets, termed lipophagy, plays a pivotal role in liver lipid catabolism, and the amelioration of NAFLD (29,109,982). During the development of …
Role of lipid microdomains in TLR-mediated signalling
Sep 1, 2015 · Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains
Physiological accumulation of lipid droplets in newborn liver …
Finally, we investigated the role of Toll-like receptor 4 (TLR4) signaling in fat storage using knockout mice and cell-specific deletion strategies. Results: Newborn mice displayed a …
Finally, we investigated the role of Toll-like receptor 4 (TLR4) signaling in fat storage using knockout mice and cell-specific deletion stra-tegies. Newborn mice displayed a dramatic …
Alarmin-loaded extracellular lipid droplets induce airway …
Genetic inhibition of LD accumulation in ILC2s significantly decreased extracellular HMGB1 abundance and BALF neutrophil infiltration. These findings unveil a previously uncharacterized …
TLR4-dependent signaling drives extracellular catabolism of low …
We present a new signaling mechanism for macrophage lipid accumulation in which aggregated LDL (agLDL) is involved in activation of toll-like receptor 4 (TLR4), resulting in local actin …
TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives …
Oct 10, 2019 · Here, we show that, in addition to its role in innate immunity, TLR4 can regulate lipid accumulation during macrophage catabolism of agLDL, and we demonstrate a signaling …
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