Dec 9, 2022 · Toll-like receptor 7 (TLR7) agonists augment immune activity and have potential for the treatment of chronic hepatitis B virus (HBV) infection. We aimed to assess the safety and tolerability of RO7020531 (also called RG7854), a prodrug of the TLR7 agonist RO7011785, in healthy volunteers and patients with chronic HBV infection.

Aug 1, 2016 · It appears that defective expression of TLR7 may result in impaired immune responses against HBV. The aim of this review is to address the recent information regarding the crucial roles played by TLR7 in hepatitis B infection and also the main mechanisms used by HBV to escape from recognition by TLR7 in prolonged HBV infected patients.

Jul 29, 2020 · We found that CM from PBMCs stimulated with dual-acting TLR7/8 (R848) and TLR2/7 (CL413) agonists were more potent drivers of inhibition of HBe and HBs antigen secretion from HBV-infected...

Mar 29, 2018 · The use of PRR agonists, in particular TLR7-L (TLR7-Ligands), to induce endogenous IFNs and other cytokines, has been successfully applied to animal models of HBV infection.

Mar 4, 2020 · We designed and evaluated an HBV therapeutic vaccine consisting of a novel Toll-like receptor 7 (TLR7) agonist T7-EA, an Alum adjuvant and a recombinant HBsAg protein. We used RNA-seq, ELISA and hTLR7/8 reporting assays to characterize T7-EA in vitro and real-time PCR to evaluate the tissue-retention characteristics in vivo.

Sep 29, 2021 · 基于新型TLR7激动剂（命名为T7-EA）、明矾佐剂和重组HBsAg 蛋白组成的HBV治疗性疫苗评估表明，T7-EA诱导 h1型免疫反应，以及增加小鼠模型中T细胞反应和HBsAg 特异性 IgG2a 滴度。

Jan 14, 2017 · In the present study we have tried to look into the antiviral role of TLR7 in hepatocyte microenvironment during HBV infection. TLR7 exhibits viral clearance by modulating several key host factors. Cell cycle analysis was carried out to check the fate of HBV induced G1/S arrest on TLR7 activation.

Background & aims: The oral Toll-like receptor (TLR) 7 agonist GS-9620 has antiviral effects in woodchuck and chimpanzee models of chronic hepatitis B virus (HBV) infection. We investigated, in a clinical trial, the capacity of this agent to reconstitute protective immunity in patients with chronic HBV infection.

Jul 3, 2024 · HBV-neutralizing antibody 129G1 was linked with a TLR7/8 agonist small molecule compound IMDQ. Treatment with 129G1-IMDQ has shown significant promise in lowering HBsAg levels in AAV/HBV mice. 129G1-IMDQ were eliciting a strong and lasting anti-HBsAg immune response after short-term treatment in AAV/HBV mice.

Dec 1, 2021 · In humans, toll-like receptor-7 (TLR7) is expressed on plasmacytoid dendritic cells (pDCs) and B cells (Schurich et al., 2013; Kurktschiev et al., 2014). In pDCs, TLR7 activation leads to an antiviral immune response, with production of IFNα and pro-inflammatory cytokines.