2022年7月28日 · 三级淋巴结构 (TLS, Tertiary lymphoid structures) 是指在非淋巴组织中发现的类淋巴结构。 TLS 多见于多种处于发炎状态的组织中，可驱动免疫细胞活化，其形成与慢性炎性疾病、自身免疫病和癌症等多种慢性疾病有关。 在肿瘤环境中，TLS 可促进免疫细胞浸入实体瘤，因而 TLS 的发展与未经治疗的患者的生存率显著相关。 同样地，在接受免疫检查点抑制剂治疗的患者中，TLS 的发展通常与改善的治疗反应有关。 这提示了 TLS 是产生抗肿瘤免疫位点的猜想。 因 …

In the setting of tumors, TLSs facilitate the influx of immune cells into the tumor site and have therefore attracted interest as a means of improving anticancer immunity and favorable treatment response in patients. Schumacher and Thommen review the biology of TLSs and outline recent advances in TLS research.

2024年8月8日 · Here, we summarize the current views on the composition of TLS at different stages of their development. We also discuss the role of B cells and T cells associated with TLS and their...

2022年3月2日 · The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive clinical outcomes and responses to immunotherapy in cancer. Here, we used spatial transcriptomics to examine the nature of B cell responses within TLS in renal cell carcinoma (RCC). B cells were enriched in T …

2019年5月15日 · Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-lymphoid tissues at sites of chronic inflammation including tumours. Key common...

2024年8月28日 · Tertiary lymphoid structures (TLSs) are organized, non-encapsulated aggregates of lymphoid cells that form in non-lymphoid tissues under pathological conditions after birth....

2024年8月12日 · Here, we reveal that intra- and peri-tumor mature TLSs (TLS+) are associated with improved clinical outcomes than TLS− tumors. Using single-cell-RNA-sequencing and spatial-enhanced-resolution-omics-sequencing (Stereo-seq), we reveal that TLS+ tumors are enriched with IgG + plasma cells (PCs), while TLS− tumors are characterized with IgA + PCs.

The TLS consists of T-cell and B-cell-rich regions, as well as plasma cells, follicular helper T cells, follicular dendritic cells (FDCs), germinal centers (GCs) and high endothelial venules. TLSs can be divided into different subtypes and mature stages according to the density of FDCs and GCs.

2023年9月11日 · Here, we review the role of tertiary lymphoid structures (TLS) in the generation of T and B cell immunities, focusing on the impact of B cells that undergo full maturation, resulting in the generation of plasma cells (PCs) producing high-affinity IgG and IgA antibodies.

2025年1月10日 · Tertiary lymphoid structures (TLSs) are organized ectopic lymphoid aggregates within the tumor microenvironment that serve as crucial sites for the development of adaptive antitumor cellular and humoral immunity.