2018年12月6日 · TLT-1 is a type-1 transmembrane protein that is highly and exclusively expressed in megakaryocytes and platelets. 2-4 Structurally, it consists of a single immunoglobulin-variable domain in its extracellular region, a transmembrane domain, and a cytoplasmic tail containing 2 highly conserved tyrosine residues, 1 of which is found within an ...

研究人员在血小板上发现了在髓细胞中表达的触发受体（TREM）样转录本（TLT）-1，可结合纤维蛋白原，介导血块形成。 因而研究人员推测血小板通过TLT-1主导ALI/ARDS的进展。 为证明上述推测，研究人员回顾性检测ARDSNET临床试验样本的血浆s. 每年超过20万人罹患急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS），死亡率高达40%。 虽然血小板也参与ALI/ARDS进展，但其确切作用尚不明确。 研究人员在血小板上发现了在髓细胞中表达的触发受体（TREM） …

2020年3月20日 · TLT-1 binds fibrinogen and plays a role in bleeding initiated by inflammatory insults. Here, we describe a proteomics screen that maps the TLT-1 interactome in resting and activated human platelets. Several identified TLT-1 interactors are involved in cell adhesion and migration, as well as platelet activation.

2021年11月5日 · This study demonstrates that TLT-1 is a novel platelet ligand for VWF, and that TLT-1 may preferentially bind VWF over fibrinogen. We propose a TLT-1/VWF dependent integrin αIIbβ3 activation mechanism which plays a pivotal role in thrombus formation under non-inflammatory and potentially inflammatory conditions.

2018年12月6日 · Infusion of sTLT-1 restores normal fibrinogen deposition and reduces pulmonary hemorrhage by 40% (P ≤ .001) and tissue damage by 25% (P ≤ .001) in vivo. Our findings suggest that TLT-1 uses fibrinogen to govern the transition between inflammation and hemostasis and facilitate controlled leukocyte transmigration during the progression of ARDS.

2021年11月23日 · TREM-Like Transcript-1 (TLT-1) is a platelet specific receptor found in the a-granules of platelets and released to the surface upon platelet activation. TLT-1 is a type 1 receptor that, like the integrin a2bb3, binds fibrinogen and facilitates platelet aggregation .

The triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is an abundantly expressed platelet receptor and its deletion leads to hemorrhage and edema after lipopolysaccharide and TNF-α treatment.

2021年11月5日 · TREM-Like Transcript-1 (TLT-1) 是一种血小板特异性受体，存在于血小板的 a 颗粒中，并在血小板活化后释放到表面。TLT-1 是一种 1 型受体，与整合素 a2bb3 一样，结合纤维蛋白原并促进血小板聚集。

2008年11月16日 · TREM-like transcript-1 (TLT-1) is a novel, platelet-specific, membrane protein that is stored in a-granules and brought to the platelet surface upon activation. Little is known about its function. Here we build upon our recent findings that a soluble fragment of TLT-1 (sTLT) is released upon platelet activation and can be detected in the serum ...

2020年3月20日 · TLT-1 binds fibrinogen and plays a role in bleeding initiated by inflammatory insults. Here, we describe a proteomics screen that maps the TLT-1 interactome in resting and activated human platelets. Several identified TLT-1 interactors are involved in cell adhesion and migration, as well as platelet activation.