Substrate transport and drug interaction of human thiamine
2024年12月30日 · Here we present ten cryo-EM structures of human thiamine transporters SLC19A3 and SLC19A2 in outward- and inward-facing conformations, complexed with …
Allosteric drug transport mechanism of multidrug transporter AcrB - Nature
2021年6月29日 · In this work, we address three main questions: (1) How are drugs transported through the channels (CH1–CH4) towards the drug-binding pockets (AP and DBP) and is …
Extracellular domain of PepT1 interacts with TM1 to facilitate ...
2022年7月7日 · Here we report the structure of horse PepT1 encircled in lipid nanodiscs and captured in the inward-open apo conformation. The structure shows that the ECD bridges the …
谈谈抗体药物结构表征的那些事 点击上方的 行舟Drug 添加关注
2023年4月22日 · 通常用DSC（differential scanning calorimetry）来表征抗体的热稳定性，用Tm（溶解温度）表示，Tm越高表示抗体分子越稳定。图5是生物类似药与原研药表征时Tm的 …
Dopamine reuptake and inhibitory mechanisms in human …
2024年8月7日 · Here we report structures of the human dopamine transporter in its apo state, and in complex with the substrate dopamine, the attention deficit hyperactivity disorder drug …
IMM2520, a novel anti-CD47/PD-L1 bispecific antibody for cancer …
2024年11月15日 · An ideal therapeutic drug targeting CD47 should selectively prompt macrophages to engulf tumor cells, activate T cells, and avoid binding to RBCs. Compared …
Transport mechanism and pharmacology of the human GlyT1
This work reports the structures of human glycine transporter 1 (GlyT1), providing insights on its substrate recognition, conformational transition, and distinct binding pockets for anti …
Structural basis for GLP-1 receptor activation by LY3502970, an …
Glucagon-like peptide-1 receptor (GLP-1R) agonists are efficacious antidiabetic medications that work by enhancing glucose-dependent insulin secretion and improving energy balance. …
Structural snapshots of human PepT1 and PepT2 reveal ... - Science
2021年11月3日 · Besides the uptake of short peptides, peptide transporter 1 (PepT1) is a highly abundant drug transporter in the intestine and represents a major route for oral drug delivery. …
Modulation of the human GlyT1 by clinical drugs and cholesterol
2025年3月11日 · Apart from the direct interactions mentioned above, residues such as G65 TM1, G67 TM1, G319 TM6, and G324 TM6 are likely to play significant roles in providing sufficient …