Structures of the TMC-1 complex illuminate mechanosensory …
2022年10月12日 · Here we report the single-particle cryo-electron microscopy structure of the native transmembrane channel-like protein 1 (TMC-1) mechanosensory transduction complex …
TMC1 - Wikipedia
Transmembrane channel-like protein 1 is a protein that in humans is encoded by the TMC1 gene. [5][6][7] TMC1 contains six transmembrane domains with both the C and N termini on the …
Structural insights into calcium-dependent CIB2-TMC1 ... - Nature
2025年2月25日 · Here, our study unveils CIB2/3’s role as a calcium sensor in its interaction with TMC1. Utilizing X-ray crystallography, we elucidate the high-resolution structure of the …
TMC1 Gene - GeneCards | TMC1 Protein | TMC1 Antibody
2024年12月25日 · TMC1 (Transmembrane Channel Like 1) is a Protein Coding gene. Diseases associated with TMC1 include Deafness, Autosomal Dominant 36 and Deafness, Autosomal …
Ectopic mouse TMC1 and TMC2 alone form mechanosensitive …
2025年2月25日 · We have reported several notable findings: 1) A Fyn lipidation tag enhances cell-surface expression of mouse and human TMC1/2, helping to overcome longstanding …
Improved TMC1 gene therapy restores hearing and balance in …
2019年1月22日 · To develop treatments for genetic inner ear disorders, we designed gene replacement therapies using synthetic adeno-associated viral vectors to deliver the coding …
Human TMC1 and TMC2 are mechanically gated ion channels
2025年2月5日 · Mammalian transmembrane channel-like proteins 1 and 2 (TMC1 and TMC2) have emerged as very promising candidate mechanotransduction channels in hair cells. …
TMC1 Forms the Pore of Mechanosensory Transduction Channels …
2018年8月22日 · Here, we provide biochemical evidence suggesting TMC1 assembles as a dimer, along with structural and sequence analyses suggesting similarity to dimeric TMEM16 …
首都医学科学创新中心-Neuron｜闫致强团队揭示人类TMC1和TMC…
该项研究成功突破了哺乳动物tmc1和tmc2 (tmc1/2)蛋白在细胞系内异源表达无法定位在细胞膜上的难题，证明了人类tmc1/2是机械力门控离子通道，提供了其在毛细胞上作为听觉受体的决定性 …
TMC1 Forms the Pore of Mechanosensory Transduction Channels in ...
2018年8月22日 · We propose that TMC1 is structurally similar to TMEM16 channels and includes ten transmembrane domains with four domains, S4-S7, that line the channel pore. The data …
- 某些结果已被删除