Transmembrane protease, serine 6 (also known as matriptase-2) is an enzyme that in humans is encoded by the TMPRSS6 gene. [5] Based on twin studies, mutations in TMPRSS6 gene …

2024年12月25日 · TMPRSS6 (Transmembrane Serine Protease 6) is a Protein Coding gene. Diseases associated with TMPRSS6 include Iron-Refractory Iron Deficiency Anemia and …

At least 40 mutations in the TMPRSS6 gene have been found to cause an inherited form of anemia called iron-refractory iron deficiency anemia. This condition is characterized by a …

2023年1月23日 · TMPRSS6 functions as a negative regulator of the expression of the systemic iron-regulatory hormone hepcidin. Over the last decade and a half, growing understanding of …

2024年1月13日 · In the present study, we found that Tmprss6 markedly inhibited mouse neuroblastoma N2a (neuro-2a) cell proliferation and tumor growth in nude mice. Tmprss6 …

2025年1月4日 · TMPRSS6 mutations are associated with iron-refractory iron deficiency anemia. Article summarized the functional relevance of matriptase-2 in iron metabolism. TMPRSS6 …

2023年9月25日 · 9MW3011是迈威生物在美国 San Diego的创新研发中心自主研发的，属性为治疗用生物制品1类的抗TMPRSS6 单克隆抗体 。 该药物的靶点主要表达在肝细胞膜表面，通过 …

TMPRSS6 functions as a negative regulator of the expression of the systemic iron-regulatory hormone hepcidin. Over the last decade and a half, growing understanding of TMPRSS6 …

铁调素由Hamp基因编码，其表达由BMP、STAT等多条信号通路调控，白细胞介素 (IL)-6、跨膜丝氨酸蛋白酶 (TMPRSS)6等信号分子亦在铁调素的调节中发挥重要作用。 笔者现就铁调素的分 …

TMPRSS6是一种基因，变异后就会“沉默”，如果缺乏TMPRSS6 基因编码的蛋白质，人体内就会产生过多Hepcidin激素。 正常情况下，这种激素负责控制人体不要过量吸收铁。