Trimethylsilyl chloride, also known as chlorotrimethylsilane is an organosilicon compound (silyl halide), with the formula (CH 3) 3 SiCl, often abbreviated Me 3 SiCl or TMSCl. It is a colourless volatile liquid that is stable in the absence of water.

Primary alcohols dehydrate through the E2 mechanism. The hydroxyl oxygen donates two electrons to a proton from sulfuric acid (H 2 SO 4), forming an alkyloxonium ion. Then the conjugate base, HSO 4–, reacts with one of the adjacent (beta) hydrogen atoms while the alkyloxonium ion leaves in a concerted process, forming a double bond.

We have developed a facile method to synthesize different amino acid methyl ester hydrochlorides through the esterification of corresponding amino acids with methanol using trimethylchlorosilane. The reaction offers convenience, mild …

Methanolic solution of 2-hydroxy-4- (tetradecyloxy)benzaldehyde (0.33 gm, 1 mmol) was added drop wise to the solution of glycine methyl ester hydrochloride (1 mmol) in methanol and then tri-ethyl...

2018年11月5日 · Herein, we report an approach in which the commercially available heteropolyacid H 3 PW 12 O 40 in a CH 3 CN/iso-octane biphasic system can photocatalytically activate dioxygen to convert most thiophenic species to H 2 SO 4 (yield ∼ 75%).

Chlorotrimethylsilane (TMSCl) was a highly efficient catalyst in the allylic alkylation of 1,3-diaryl-2-propenyl acetates with a diethylzinc reagent, in which various 1,3-diaryl-2-propenyl acetates are efficiently transferred to 1,3-diarylpent-1-enes in good to excellent yields.

By protecting the alcohol group with TMSCl, we prevent the alcohol from reacting with HBr, allowing the reaction to proceed on the alkene: The silyl ether is removed easily by reacting with Tetra-n-butylammonium fluoride (TBAF) in acidic conditions (H3O+): The reaction mechanism is …

2023年9月6日 · Trimethylsilyl chloride (TMSCl) is commonly used to “activate” metal (0) powders toward oxidative addition of organohalides, but knowledge of its mechanism remains limited by the inability to characterize chemical intermediates under reaction conditions.

The combination of chlorotrimethylsilane (TMSCl) with sodium iodide (NaI) has been used as a versatile reagent association in a variety of chemical transformations as the cleavage of ethers, esters, lactones, carbamates, and for the conversion …

1995年12月4日 · Replacing TMSCl with triisopropylsilyl chloride (TIPSCl) or TBDMSCl gave good results due to the stability of these silyl enol ethers. Unfortunately, the organolithium species derived from 5 and 6 by sulfur-lithium exchange gave low yields upon reaction with electrophiles such as methyl iodide, benzaldehyde. and methyl vinyl ketone Table 3.