每个转位子都带有3个基因：一个是编码对氨苄青霉素抗性的β-内酰胺酶（β-lactamase）基因，另外2个是与转位作用有关的基因。 其中一个叫做TnpA基因，编码一种长度为1015个氨基酸的转位酶；另一个叫做TnpR基因，它编码较小的蛋白质，只有185个氨基酸。 此种较小的蛋白质有两种功能，一种是抑制TnpA基因的合成活性；另一种是促进在中间分解区发生位点特异的切割。 [1] 1 吴乃虎. 基因工程原理（上册） [M]. 第2版. 北京:科学出版社, 1998:20-21. 根据结构特征的不同， …

2022年10月18日 · Tn3 is a widespread family and among the first identified bacterial transposons famed for their contribution to the dissemination of antibiotic resistance. Transposition within this family is...

Transposons of the Tn 3 family form a widespread and remarkably homogeneous group of bacterial transposable elements in terms of transposition functions and an extremely versatile system for mediating gene reassortment and genomic plasticity owing …

Transposons of the Tn3 family form a widespread and remarkably homogeneous group of bacterial transposable elements in terms of transposition functions and an extremely versatile system for mediating gene reassortment and genomic plasticity owing …

2024年8月9日 · Tn 3 family transposons are a widespread group of replicative transposons, notorious for contributing to the dissemination of antibiotic resistance, particularly the global prevalence of carbapenem resistance. The transposase (TnpA) of these elements catalyzes DNA breakage and rejoining reactions required for transposition.

Tn3 是一个分布广泛的家族，是最早发现的细菌转座子之一，以其对传播抗生素耐药性的贡献而闻名。 该家族内的转座由大的 TnpA 转座酶介导，它促进转座和靶免疫。 然而，缺乏理解 TnpA 转座机制所需的结构框架。 在这里，我们以载脂蛋白形式描述了 TnpA 来自 Tn4430 的低温电子显微镜结构，并在 DNA 切割和链转移前后与转座子末端配对。 我们表明 TnpA 具有不寻常的结构，并展示了涉及 RNase H 样催化结构域变质再折叠的家族特定调节机制。

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Ejercicios TEMA 4 – NÚMEROS ENTEROS (1º ESO) Página 3 EL CONJUNTO DE LOS NÚMEROS ENTEROS “Z” El conjuto Z de los números enteros está formado por: Los números naturales, que son los positivos → +1, +2, +3, +4 ……. El cero → 0 Los correspondientes negativos → -1. -2. -3, -4 …….

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