The Total Nucleated Cell count or TNC is the test most often reported as a measure of the cell count after cord blood processing. The main advantage of measuring TNC is that the count is highly reproducible within and among labs, so it can be used accurately throughout the blood banking community.

The measurement of Total Nucleated Cells (TNC) in cerebrospinal fluid (CSF), as part of a cell count with differential, is a critical parameter in the diagnostic evaluation of neurological conditions.

Excluding red blood cells and platelets that do not have a nucleus, TNC measures the starting number of nucleated cells in a sample of bone marrow concentrate. These are cells with a nucleus, a copy of the genome, and the cellular machinery required for gene expression.

2023年10月2日 · The total nucleated cell (TNC) count is the most widely used and re-producible method for determining the relative potency of a cord blood collection. It is also an automated process that makes it easy for busy labs to proctor.

Ideally both the total nucleated cell (TNC) count and the viability of the cells should be assessed. Researchers generally use Trypan Blue for both TNC and cell viability counts. However for samples containing red blood cells (RBCs), it is often difficult to distinguish nucleated cells from RBCs using Trypan Blue alone.

2011年1月11日 · The TNC count was the best parameter to identify CB units having 2 × 10 6 or more CD34+ cells, with an area under the ROC curve of 0.828 (95% confidence interval, 0.800–0.856; P < .01) and an efficiency of 75.4%. Combination of parameters (TNC/mononuclear cells [MNCs], efficiency 74.7%; TNC/volume, efficiency 68.9%; and volume/MNCs ...

→ Diagnostic Significance: TNCC is a valuable diagnostic tool in identifying the underlying cause of joint symptoms. It is often used in conjunction with other synovial fluid parameters, such as synovial fluid appearance, crystal examination, and microbiological testing, to …

TNC content is evaluated routinely by hematology analyzers (HA) as WBC counts. The objective of the study was to compare TNC content utilizing two different HA, one utilizing an impedance channel and optical channel, and the other using only an optical channel.

Firstly, we measure the overall total nucleated cell (TNC) count in the sample. Within the TNC fraction, we analyse the viable stem cell content (CD34+ cells). The TNC fraction includes all the white blood cells present in the cord blood and is used as an initial cell count screening test.

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