Tumor necrosis factor superfamily - Wikipedia
The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily …
肿瘤坏死因子TNF家族及其受体基础概述 - 知乎
肿瘤坏死因子（TNF）是在能够杀死小鼠中的癌细胞的血清中发现的细胞因子。 现在已经发现的肿瘤坏死因子超家族包括19个配体和29个不同的受体。
TNF receptors: Structure-function relationships and therapeutic ...
2025年1月1日 · Tumor necrosis factor (TNF) is a highly pleiotropic cytokine that binds its cognate receptors, TNF receptor 1 and 2 (TNFR1 and TNFR2), and powerfully influences diverse …
The TNF Family of Ligands and Receptors: Communication …
2019年1月1日 · The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF) include 19 ligands and 29 receptors that play important roles in the …
肿瘤坏死因子-TNF超家族 - 翌圣生物
目前发现的TNF超家族蛋白（TNFSF）配体19种和受体29种。 主要由免疫细胞表达，包括TNF、CD40L、TNFSF13B等，生物学功能涉及免疫调节、凋亡、炎症、感染性休克，并与肿瘤、癌 …
The molecular architecture of the TNF superfamily - ScienceDirect
2002年1月1日 · Ligands of the TNF (tumour necrosis factor) superfamily have pivotal roles in the organization and function of the immune system, and are implicated in the aetiology of several …
The Tumor Necrosis Factor Family: Family Conventions and …
The tumor necrosis factor (TNF) cytokine family and the TNF/nerve growth factor (NGF) family of their cognate receptors together control numerous immune functions, as well as tissue …
肿瘤坏死因子TNF配体及受体超家族成员 - 知乎
TNF配体是膜锚定或可溶性三聚体，一般来说，一个三聚体配体与三个单体受体结合，激活细胞内信号通路。 通过基于系统流式细胞术的分析，Bossen等人证明了调节小鼠和人 …
Structural principles of tumor necrosis factor superfamily signaling
Tumor necrosis factor (TNF) superfamily pathways regulate cell proliferation, cell death, and morphogenesis. TNF superfamily receptors mediate various cancers and immune-mediated …
Signalling pathways of the TNF superfamily: a double-edged sword
2003年9月1日 · 19 ligands and 29 receptors that belong to the tumour-necrosis factor (TNF) superfamily have been identified. At the cellular level TNF-superfamily members promote …