2024年12月25日 · TNF (Tumor Necrosis Factor) is a Protein Coding gene. Diseases associated with TNF include Immunodeficiency 127 and Asthma. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TNFR1 Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and cytokine activity.

Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. [5] TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. [6]

2025年2月8日 · This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.

Tumor necrosis factor (TNF) is a critical cytokine, which contributes to both physiological and pathological processes. This mini-review will briefly touch the history of TNF discovery, its family members and its biological and pathological ...

2022年11月15日 · Tumour necrosis factor (TNF) drives inflammatory responses directly by inducing inflammatory gene expression and also indirectly by inducing cell death.

Tumor necrosis factor alpha (TNF-α) is a cytokine that has pleiotropic effects on various cell types. It has been identified as a major regulator of inflammatory responses and is known to be involved in the pathogenesis of some inflammatory and autoimmune diseases .

Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine with an important role in the pathogenesis of several diseases. Its encoding gene is located in the short arm of chromosome 6 in the major histocompatibility complex class III region.

肿瘤坏死因子 （TNF）是在能够杀死小鼠中的癌细胞的血清中发现的细胞因子。 现在已经发现的肿瘤坏死因子超家族包括19个配体和29个不同的受体。 TNF超家族 的配体成员主要要 NF-kB 配体的TNF-α、TNF-β、淋巴毒素-β、CD40L、FasL、CD30L、4-1BBL、CD27L和OX40L，TNF相关凋亡诱导配体（TRAIL），LIGHT受体激活剂（RANKL），TNF相关的凋亡诱导因子（TWEAK），增殖诱导配体（APRIL），B细胞激活因子（BAFF），血管内皮细胞生长抑制 …

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.

2025年2月11日 · This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure.