PTEN gene triggers cells to undergo apoptosis and promotes myocardial dysfunction. Several TNF family cytokines are elevated during acute myocardial infarction (AMI). Their role in predicting subsequent prognosis in these setting remains poorly ...

2007年2月1日 · TNF-α increased PTEN expression at HL-60 cells in a time- and dose-dependent manner, but the response was abolished by disruption of NF-κB with p65 anisense phosphorothioate oligonucleotide...

NF-κB prevents cell death caused by tumor necrosis factor (TNF) and other genotoxic insults by directly inducing antiapoptotic target genes. We report here that the tumor suppressor PTEN, which functions as a negative regulator of phosphatidylinositol (PI)-3 kinase/Akt-mediated cell survival pathway, is down regulated by p65 but not by p50.

2019年4月29日 · Patients with acute myocardial infarction had statistically significant increased serum levels of PTEN & TNF-α gene activity. Both markers predict worsening of left ventricular systolic functions, development of heart failure and death.

2006年11月11日 · The present study showed that PTEN targets the antiapoptotic gene NFκB induced by TNF-α by suppressing several TNF-induced antiapoptotic gene products, thereby confirming our hypothesis that PTEN mediates its effects by modulating NFκB and identifying a function of PTEN in its role as a tumor suppressor.

2016年8月25日 · TNF-α induces vascular insulin resistance by mechanisms that involve positive modulation of PTEN and inhibition of Akt/eNOS/NO signaling. Our findings highlight TNF-α and PTEN as potential targets to limit insulin resistance and vascular complications associated with obesity-related conditions.

Notch1 inhibition significantly repressed TNF-α-induced ASM cell proliferation and migration, while Notch1 overexpression promoted the opposite effect. Moreover, Notch1 inhibition downregulated the expression of Notch-1 intracellular domain (NICD) and Hes1, while upregulated PTEN expression in TNF-α-exposed cells.

2014年6月6日 · This study investigated a possible role for TLR4-mediated PTEN/PI3K/AKT/NF-κB signaling in hippocampal neurons during the neuroinflammatory response, which was induced by LPS or blocked by application of an antibody against TLR4, or dipotassium bisperoxo (pyridine-2-carboxyl) oxovanadate [bpV (pic)] and pyrrolidine dithiocarbamate (PDTC ...

2020年11月1日 · Notch1 regulates PTEN via Hes1 in TNF-α-exposed ASM cells. Notch1 has been implicated in asthma pathogenesis. However, the function of Notch1 in regulating airway smooth muscle (ASM) cell proliferation and migration during airway remodeling of …

2019年6月1日 · We assessed serum levels of PTEN gene activity & TNF-α in acute ST elevation myocardial infarction and determined the impact of their levels on both left ventricular function and the clinical outcome in these patients.