TNO’s patented in vitro gastrointestinal model TIM offers rapid insight into the into the release, solubility and availability for absorption of pharmaceuticals within the gastrointestinal tract. This well-validated and accurate system has a much greater in vivo predictive value than typical in vitro dissolution assays.

The TNO Gastro-Intestinal Model (TIM) is a multi-compartmental model, designed to realistically simulate conditions in the lumen of the gastro-intestinal tract. TIM is successfully used to study the gastro-intestinal behavior of a wide variety of feed, food and pharmaceutical products.

TNO (gastro-) Intestinal Models (“TIM”) is a system of models mimicking the digestive tract. The system was developed by TNO, the Netherlands Organisation for Applied Scientific Research. [1]

Using TIM, TNO can conduct a detailed analysis of the release, solubility and bioaccessibility profile of a compound, as well as other physico-chemical properties or pharmaceutical interactions during gastrointestinal transit. Each compartment can be studied separately, measuring even relatively small changes in bioactive components.

Our TIM-1 System, with a horizontal stomach compartment & 3 segments of the small intestine (duodenum, jejunum & ileum), precisely mimics the upper GI tract & all physiologically relevant processes. With it’s ileal affluent compartment, we address both accessible and inaccessible fractions of your formulation.

The TNO computer-controlled, dynamic in vitro gastro-Intestinal Model of the colon (nick-named TIM-2; Fig. 26.1) was developed by TNO some 15 years ago (Minekus et al. 1999). It is based on the TIM-1 system (the TNO in vitro gastro-intestinal model of the stomach and small intestine) that is discussed elsewhere in this book.

2022年6月1日 · The tiny-TIM system equipped with the advanced gastric compartment is one of the most realistic in vitro models for the simulation of the physiological processes occurring in human stomach and small intestine.

This contribution describes the development and use of the TNO in vitro model of the colon (TIM-2). The unique features of this system are briefly discussed, as well as how these contribute to the predictability of this validated in vitro model for clinical trials.

The TNO Gastro-Intestinal Model (TIM) is a multi-compartmental model, designed to realistically simulate conditions in the lumen of the gastro-intestinal tract. TIM is successfully used to study the gastro-intestinal behavior of a wide variety of feed, food and pharmaceutical products.

tno’s models for gastrointestinal research (tiM) represent the most advanced, patent protected platforms for studying the fate of food and food constituents during digestion in the stomach and small intestine and fermentation in the large intestine. TIM for rapId and accuraTe dIgesTIve ModellIng tiM mimics human or animal digestion